Baloch Zubair W, LiVolsi Virginia A
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, UPENN Medical Center, 3400 Spruce Street, 6 Founders Pavilion, Philadelphia, PA, 19104, USA,
Endocr Pathol. 2014 Mar;25(1):12-20. doi: 10.1007/s12022-013-9293-4.
The past 25 years has seen a marked increase in our understanding of thyroid neoplasia, from the interrelationship with radiation exposure, the definition of variants of papillary carcinoma, to the application of molecular biology techniques to capture a more basic definition of tumor development, diagnosis, and prognostic implications. No other group of thyroid tumors has been studied as much as those with follicular pattern. In this review, we present a reappraisal of these controversial lesions in light of the issues with the diagnostic problems and classification schemes of follicular thyroid lesions, with emphasis on the progress made in the past quarter century and a focus on the current persistent controversies.
在过去25年里，我们对甲状腺肿瘤的认识有了显著提高，从与辐射暴露的相互关系、乳头状癌变体的定义，到应用分子生物学技术来更深入地理解肿瘤的发生、诊断及预后意义。没有哪一组甲状腺肿瘤像具有滤泡样形态的肿瘤那样得到如此多的研究。在本综述中，我们根据滤泡性甲状腺病变的诊断问题和分类方案所涉及的问题，对这些有争议的病变进行重新评估，重点是过去四分之一世纪所取得的进展以及当前仍然存在的争议。
