Department of Laboratory, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
Intensive Care Unit, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
PLoS One. 2014 Jan 21;9(1):e85719. doi: 10.1371/journal.pone.0085719. eCollection 2014.
A single nucleotide polymorphism (SNP) in the second intron of human TERT (hTERT), rs2736100, acts as a critical factor in hTERT synthesis and activation. The rs2736100 SNP was found to be associated with susceptibility to many cancers. Recently, inhibition of telomerase and marked telomere shortening were determined to be closely associated with the increasing severity of atherosclerosis. The association between the SNP of rs2736100 and the presence of atherosclerosis was evaluated in 84 atherosclerosis patients and 257 healthy controls using multivariate logistic regression analyses. The proportion of the GG genotype in atherosclerosis patients (17.9%) was significantly higher than in the control group (9.7%). Eight variables, including age, gender, cholesterol, high density lipoprotein, homocysteine, total bilirubin, indirect bilirubin, and rs2736100 GG genotype, were associated with atherosclerosis with odds ratios of 1.88, 2.11, 1.66, 0.23, 1.27, 1.29, 1.53, and 1.74, respectively, using multivariate logistic regression analyses. Homozygous GG was demonstrated to be associated with the presence of atherosclerosis in our population.
一个单核苷酸多态性（SNP）在人类端粒酶反转录酶（hTERT）的第二内含子，rs2736100，作为 hTERT 合成和激活的关键因素。rs2736100 SNP 被发现与许多癌症的易感性有关。最近，端粒酶的抑制和明显的端粒缩短被确定与动脉粥样硬化的严重程度增加密切相关。使用多元逻辑回归分析，在 84 例动脉粥样硬化患者和 257 例健康对照中评估了 rs2736100 SNP 与动脉粥样硬化的存在之间的关联。动脉粥样硬化患者 GG 基因型的比例（17.9%）明显高于对照组（9.7%）。多元逻辑回归分析显示，包括年龄、性别、胆固醇、高密度脂蛋白、同型半胱氨酸、总胆红素、间接胆红素和 rs2736100 GG 基因型在内的 8 个变量与动脉粥样硬化有关，其比值比分别为 1.88、2.11、1.66、0.23、1.27、1.29、1.53 和 1.74。在我们的人群中，杂合子 GG 被证明与动脉粥样硬化的存在有关。
