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Evidence stacks up that endothelial insulin resistance is a culprit in atherosclerosis.越来越多的证据表明,内皮胰岛素抵抗是动脉粥样硬化的一个罪魁祸首。
Circ Res. 2013 Aug 2;113(4):352-4. doi: 10.1161/CIRCRESAHA.113.301998.
2
Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium.蛋白激酶 C-β 同工型在血管内皮中的过表达诱导血管胰岛素抵抗和内皮素-1 表达,并加速动脉粥样硬化。
Circ Res. 2013 Aug 2;113(4):418-27. doi: 10.1161/CIRCRESAHA.113.301074. Epub 2013 Jun 11.
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Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.糖尿病中的血管内皮功能障碍:分子机制与临床意义。
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Endothelial dysfunction in metabolic and vascular disorders.代谢和血管疾病中的内皮功能障碍。
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Review article: diabetes and atherosclerosis--running on a common road.综述文章:糖尿病与动脉粥样硬化——殊途同归
Aliment Pharmacol Ther. 2005 Nov;22 Suppl 2:11-5. doi: 10.1111/j.1365-2036.2005.02617.x.

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Cardiovasc Diabetol. 2023 Dec 13;22(1):339. doi: 10.1186/s12933-023-02073-2.
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Mendelian Randomization Analysis Provides Insights into the Pathogenesis of Serum Levels of Branched-Chain Amino Acids in Cardiovascular Disease.孟德尔随机化分析为深入了解心血管疾病中支链氨基酸血清水平的发病机制提供了见解。
Metabolites. 2023 Mar 9;13(3):403. doi: 10.3390/metabo13030403.
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Relationship of the metabolic score for insulin resistance and the risk of stroke in patients with hypertension: A cohort study.代谢性胰岛素抵抗评分与高血压患者卒中风险的关系:一项队列研究。
Front Endocrinol (Lausanne). 2022 Dec 5;13:1049211. doi: 10.3389/fendo.2022.1049211. eCollection 2022.
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New insights into mechanisms of endothelial insulin resistance in type 2 diabetes.2 型糖尿病中内皮胰岛素抵抗机制的新见解。
Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1231-H1238. doi: 10.1152/ajpheart.00537.2022. Epub 2022 Nov 4.
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TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice.TRAF3IP2(TRAF3 相互作用蛋白 2)介导雄性小鼠肥胖相关的血管胰岛素抵抗和功能障碍。
Hypertension. 2020 Oct;76(4):1319-1329. doi: 10.1161/HYPERTENSIONAHA.120.15262. Epub 2020 Aug 24.
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Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking.2型糖尿病患者的骨骼肌微血管胰岛素抵抗不会因八周的规律步行而得到改善。
J Appl Physiol (1985). 2020 Aug 1;129(2):283-296. doi: 10.1152/japplphysiol.00174.2020. Epub 2020 Jul 2.
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Vascular Endothelial Regulation of Obesity-Associated Insulin Resistance.肥胖相关胰岛素抵抗的血管内皮调节
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miR-29a promotes myocardial cell apoptosis induced by high glucose through down-regulating IGF-1.微小RNA-29a通过下调胰岛素样生长因子-1促进高糖诱导的心肌细胞凋亡。
Int J Clin Exp Med. 2015 Aug 15;8(8):14352-62. eCollection 2015.
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The GG genotype of telomerase reverse transcriptase at genetic locus rs2736100 is associated with human atherosclerosis risk in the Han Chinese population.端粒酶逆转录酶基因座 rs2736100 的 GG 基因型与汉族人群的人类动脉粥样硬化风险相关。
PLoS One. 2014 Jan 21;9(1):e85719. doi: 10.1371/journal.pone.0085719. eCollection 2014.
10
Urinary miR-29 correlates with albuminuria and carotid intima-media thickness in type 2 diabetes patients.2 型糖尿病患者尿 miR-29 与白蛋白尿及颈动脉内膜中层厚度相关。
PLoS One. 2013 Dec 9;8(12):e82607. doi: 10.1371/journal.pone.0082607. eCollection 2013.

本文引用的文献

1
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.血管紧张素 II 和蛋白激酶 C 激活 IRS2 丝氨酸磷酸化位点,诱导内皮细胞选择性胰岛素抵抗。
Mol Cell Biol. 2013 Aug;33(16):3227-41. doi: 10.1128/MCB.00506-13. Epub 2013 Jun 17.
2
PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.蛋白激酶 Cβ促进糖尿病载脂蛋白 E 基因敲除小鼠血管炎症和动脉粥样硬化加速。
Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1779-87. doi: 10.1161/ATVBAHA.112.301113. Epub 2013 Jun 13.
3
Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium.蛋白激酶 C-β 同工型在血管内皮中的过表达诱导血管胰岛素抵抗和内皮素-1 表达,并加速动脉粥样硬化。
Circ Res. 2013 Aug 2;113(4):418-27. doi: 10.1161/CIRCRESAHA.113.301074. Epub 2013 Jun 11.
4
The role of endothelial insulin signaling in the regulation of glucose metabolism.内皮细胞胰岛素信号在葡萄糖代谢调节中的作用。
Rev Endocr Metab Disord. 2013 Jun;14(2):207-16. doi: 10.1007/s11154-013-9242-z.
5
Insulin resistance in the vasculature.血管胰岛素抵抗。
J Clin Invest. 2013 Mar;123(3):1003-4. doi: 10.1172/JCI67166. Epub 2013 Mar 1.
6
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.Nox2 NADPH 氧化酶在与胰岛素抵抗相关的内皮细胞功能障碍中起关键作用。
Diabetes. 2013 Jun;62(6):2130-4. doi: 10.2337/db12-1294. Epub 2013 Jan 24.
7
FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.FoxOs 整合胰岛素在血管内皮中的多效作用,以保护小鼠免受动脉粥样硬化的侵害。
Cell Metab. 2012 Mar 7;15(3):372-81. doi: 10.1016/j.cmet.2012.01.018.
8
eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice.内皮型一氧化氮合酶(eNOS)通过在载脂蛋白 E (apoE)小鼠中产生相关超氧化物来保护其免受动脉粥样硬化的影响。
PLoS One. 2012;7(1):e30193. doi: 10.1371/journal.pone.0030193. Epub 2012 Jan 23.
9
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.胰岛素样生长因子-1 受体是内皮细胞中一氧化氮生物利用度和胰岛素敏感性的负调节剂。
Diabetes. 2011 Aug;60(8):2169-78. doi: 10.2337/db11-0197. Epub 2011 Jun 15.
10
Vascular gene expression in mice overexpressing human endothelin-1 targeted to the endothelium.血管内皮细胞中过表达人内皮素-1 的小鼠的血管基因表达。
Physiol Genomics. 2011 Feb 11;43(3):148-60. doi: 10.1152/physiolgenomics.00218.2009. Epub 2010 Nov 2.

Evidence stacks up that endothelial insulin resistance is a culprit in atherosclerosis.

作者信息

Kanter Jenny E, Bornfeldt Karin E

出版信息

Circ Res. 2013 Aug 2;113(4):352-4. doi: 10.1161/CIRCRESAHA.113.301998.

DOI:10.1161/CIRCRESAHA.113.301998
PMID:23908326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3841007/
Abstract
摘要