同型半胱氨酸水平与腹主动脉瘤风险：一项荟萃分析。
Homocysteine level and risk of abdominal aortic aneurysm: a meta-analysis.
作者信息
Cao Hui, Hu Xinhua, Zhang Qiang, Li Jun, Wang Junpeng, Shao Yang, Liu Bing, Xin Shijie
机构信息
Department of Vascular and Thyriod Surgery, the First Affiliated Hospital of China Medical University, Shenyang, China.
出版信息
PLoS One. 2014 Jan 21;9(1):e85831. doi: 10.1371/journal.pone.0085831. eCollection 2014.
OBJECTIVES
Previous studies have reported inconsistent findings regarding the association between elevated plasma homocysteine (Hcy) levels and abdominal aortic aneurysm (AAA). We investigated this association between Hcy levels in patients with AAA and unaffected controls by conducting a meta-analysis and systematic review.
METHODS
We conducted a systematic literature search (up to August 2013) of the PubMed database and Embase. We selected observational studies that evaluated Hcy levels in subjects with AAA compared to unaffected controls. Criteria for inclusion were the assessment of baseline Hcy and risk of AAA as an outcome. The results were presented as odd ratio (OR) and corresponding 95% confidence intervals (CI) comparing AAA patients to the control subjects.
RESULTS
7 studies with 6,445 participants were identified and analyzed. Overall, elevated plasma Hcy was associated with an increased risk of AAA (3.29; 95% CI 1.66-6.51). The pooled adjusted OR from a random effect model of only men participants in the AAA compared with the control group was 2.36 (95% CI 0.63-8.82).
CONCLUSION
This meta-analysis and systematic review suggested that Hcy significantly increased the risk of AAA.
目的
既往研究报道血浆同型半胱氨酸（Hcy）水平升高与腹主动脉瘤（AAA）之间的关联存在不一致的结果。我们通过进行一项荟萃分析和系统评价，研究了AAA患者与未受影响对照组的Hcy水平之间的这种关联。
方法
我们对PubMed数据库和Embase进行了系统的文献检索（截至2013年8月）。我们选择了评估AAA患者与未受影响对照组Hcy水平的观察性研究。纳入标准是评估基线Hcy以及将AAA风险作为结果。结果以比值比（OR）和相应的95%置信区间（CI）呈现，比较AAA患者与对照受试者。
结果
共识别并分析了7项研究，涉及6445名参与者。总体而言血浆Hcy升高与AAA风险增加相关（3.29；95%CI 1.66 - 6.51）。在AAA组中仅男性参与者与对照组相比的随机效应模型汇总调整OR为2.36（95%CI 0.63 - 8.82）。
结论
这项荟萃分析和系统评价表明Hcy显著增加了AAA的风险。
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