Hou Yangfeng, Guo Wenjun, Fan Tianfei, Li Bolun, Ge Weipeng, Gao Ran, Wang Jing
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medicine, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
Front Cardiovasc Med. 2021 Feb 5;8:630269. doi: 10.3389/fcvm.2021.630269. eCollection 2021.
Abdominal aortic aneurysm (AAA) is a cardiovascular disease with a high risk of death, seriously threatening the life and health of people. The specific pathogenesis of AAA is still not fully understood. In recent years, researchers have found that amino acid, lipid, and carbohydrate metabolism disorders play important roles in the occurrence and development of AAA. This review is aimed to summarize the latest research progress of the relationship between AAA progression and body metabolism. The body metabolism is closely related to the occurrence and development of AAA. It is necessary to further investigate the pathogenesis of AAA from the perspective of metabolism to provide theoretical basis for AAA diagnosis and drug development.
腹主动脉瘤（AAA）是一种具有高死亡风险的心血管疾病，严重威胁着人们的生命健康。AAA的具体发病机制仍未完全明确。近年来，研究人员发现氨基酸、脂质和碳水化合物代谢紊乱在AAA的发生发展中起重要作用。本综述旨在总结AAA进展与机体代谢之间关系的最新研究进展。机体代谢与AAA的发生发展密切相关。有必要从代谢角度进一步探究AAA的发病机制，为AAA的诊断和药物研发提供理论依据。
