Dai S
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Arch Int Physiol Biochim. 1987 Sep;95(3):195-201.
The cardiovascular responses of rats of different ages, ranging from 4-15 weeks (body weight 115-490 g), to acute left coronary artery ligation under pentobarbitone anaesthesia were studied. In older animals, the responses included the occurrence of ventricular tachycardia and/or fibrillation, decrease in blood pressure, and a slight increase in heart rate. On the contrary, younger rats exhibited atrioventricular block followed by ventricular arrest, and decreases in both blood pressure and heart rate. The findings demonstrate the existence of age-related cardiovascular responses to acute myocardial ischaemia in rats, and suggest that 10-15-week-old male Sprague-Dawley rats are suitable experimental animals for producing early ventricular arrhythmias by acute coronary artery ligation.
研究了4至15周龄（体重115至490克）不同年龄大鼠在戊巴比妥麻醉下急性左冠状动脉结扎后的心血管反应。在年龄较大的动物中，反应包括室性心动过速和/或颤动的发生、血压下降以及心率略有增加。相反，年轻大鼠表现为房室传导阻滞，随后出现心室停搏，血压和心率均下降。这些发现证明了大鼠对急性心肌缺血存在与年龄相关的心血管反应，并表明10至15周龄的雄性Sprague-Dawley大鼠是通过急性冠状动脉结扎产生早期室性心律失常的合适实验动物。
