成年鸡中c-myc的组织特异性甲基化

Tissue specific methylation of c-myc in adult chickens.

作者信息

Heinke C, Andersen L, Hagan S, Guise K S

机构信息

Department of Animal Science, University of Minnesota, St. Paul 55108.

出版信息

Biochem Biophys Res Commun. 1987 Nov 30;149(1):313-7. doi: 10.1016/0006-291x(87)91641-x.

DOI:10.1016/0006-291x(87)91641-x

PMID:2446622

Abstract

Methylation of cytosine in DNA has long been correlated with modulation of specific gene expression in eukaryotes. Methylation of the c-myc locus was examined in six tissues from adult Leghorn chickens. The c-myc locus was found to be variably methylated in all examined tissues, except blood, where erythrocytic DNA showed no evidence of significant methylation of c-myc. This is contrasted with the observed sever methylation of the beta actin locus and the generally high methylation patterns found in avian erythrocytic DNA.

摘要

DNA中胞嘧啶的甲基化长期以来一直与真核生物中特定基因表达的调控相关。在成年来亨鸡的六个组织中检测了c-myc基因座的甲基化情况。发现c-myc基因座在所有检测的组织中甲基化程度各不相同，但血液除外，在血液中红细胞DNA未显示出c-myc有明显甲基化的迹象。这与观察到的β肌动蛋白基因座的严重甲基化以及禽类红细胞DNA中普遍存在的高甲基化模式形成对比。