艾滋病毒感染患者中伤寒立克次体和猫立克次体的血清学调查。

Serosurvey of Rickettsia typhi and Rickettsia felis in HIV-infected patients.

作者信息

Nogueras María Mercedes, Pons Immaculada, Sanfeliu Isabel, Sala Montserrat, Segura Ferran

机构信息

Department of Infectious Diseases, Health and University Corporation "Parc Taulí"-University Institute "Parc Taulí" of the Autonomous University of Barcelona (CSUPT), Sabadell, Spain.

出版信息

Microbiol Immunol. 2014 Apr;58(4):257-9. doi: 10.1111/1348-0421.12138.

DOI:10.1111/1348-0421.12138

PMID:24467705

Abstract

Consistent with the effects of HIV on cell-mediated immunity, an increased susceptibility to intracellular microorganisms has been observed. Rickettsiae are obligate intracellular microorganisms. The aim of this study was to examine Rickettsia typhi and Rickettsia felis infections in HIV+ population. Sera of 341 HIV+ patients were evaluated by indirect immunofluorescent assay. Age, sex, residential locality, risk behavior, stage according to criteria of the Center for Disease Control and Prevention, CD4+/CD8+ T cells, Hepatitis B antigen, and Hepatitis C serology were surveyed. Seroprevalences of R. typhi and R. felis infection were 7.6% and 4.4%, respectively. No associations were found between seropositivities and the assessed variables. Findings were similar to those obtained in healthy subjects from the same region.

摘要

与HIV对细胞介导免疫的影响一致，已观察到对细胞内微生物的易感性增加。立克次氏体是专性细胞内微生物。本研究的目的是检测HIV阳性人群中的伤寒立克次氏体和猫立克次氏体感染。通过间接免疫荧光法评估了341例HIV阳性患者的血清。调查了年龄、性别、居住地区、危险行为、根据疾病控制和预防中心标准划分的阶段、CD4+/CD8+ T细胞、乙肝抗原和丙肝血清学。伤寒立克次氏体和猫立克次氏体感染的血清阳性率分别为7.6%和4.4%。未发现血清阳性与评估变量之间存在关联。研究结果与来自同一地区的健康受试者相似。