Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, 3C Pawińskiego Street, 02-106, Warsaw, Poland.
AmerLab Ltd. Diagnostic Laboratory of Parasitic Diseases and Zoonotic Infections, Biological and Chemical Research Centre, 101 Żwirki and Wigury Street, 02-089, Warsaw, Poland.
Sci Rep. 2019 Feb 14;9(1):2117. doi: 10.1038/s41598-019-38755-9.
The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland (B. burgdorferi s.l., A. phagocytophilum, Ehrlichia spp., Babesia spp., Rickettsia spp. Bartonella henselae) to assess the frequency of exposure to such microorganisms in immunocompetent and immunocompromised individuals in endemic regions for I. ricinus ticks. Serum samples were collected from 227 HIV-infected patients and 199 blood donors. All samples were analyzed for antibodies against six tick-borne pathogens and seroprevalence rates were statistically compared between two tested group as well as age, sex and lymphocyte T CD4+ level in HIV infected patients. The seroprevalence of tick-borne infections in HIV-infected patients is higher than that of the healthy population in Poland, although no association between serological status of patients and lymphocyte CD4+ T cell level has been observed. The frequency of tick-borne coinfections and doubtful results of serological tests were significantly higher in HIV-positive individuals. In Poland, the possibility of tick-borne diseases transmission with blood is rather negligible.
我们的研究目的是评估在波兰的 HIV 感染者和献血者中六种通过蜱传播的病原体（螺旋体属、嗜吞噬细胞无形体、埃立克体属、巴贝斯虫属、无形体属、巴尔通体属）的血清流行率，以评估在地方性 Ixodes ricinus 蜱流行地区免疫功能正常和免疫功能低下个体中接触此类微生物的频率。从 227 名 HIV 感染者和 199 名献血者中采集血清样本。对所有样本进行了针对六种蜱传病原体的抗体分析，并对两个测试组之间以及 HIV 感染者的年龄、性别和淋巴细胞 T CD4+水平的血清流行率进行了统计学比较。尽管未观察到患者的血清学状态与淋巴细胞 CD4+ T 细胞水平之间存在关联，但 HIV 感染者的蜱传感染血清流行率高于波兰健康人群。在 HIV 阳性个体中，蜱传合并感染和可疑血清学检测结果的频率明显更高。在波兰，通过血液传播蜱传疾病的可能性相当低。
