Social, Cognitive and Affective Neuroscience (SCAN) Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria.
Social, Cognitive and Affective Neuroscience (SCAN) Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria.
Brain Stimul. 2014 Mar-Apr;7(2):226-33. doi: 10.1016/j.brs.2013.11.003. Epub 2013 Nov 16.
TMS has high potential as smoking cessation treatment. However, the neural mechanisms underlying TMS induced reduction of tobacco craving remain unclear. Electroencephalographic (EEG) delta frequency has been associated with the activity of the dopaminergic brain reward system, which is crucial for nicotine induced effects, and decreases after nicotine admission in smokers.
The aim of this study was to investigate EEG delta power changes induced by hf rTMS of the left dorsolateral prefrontal cortex (DLPFC) in nicotine deprived smokers and it's relation to cue-induced nicotine craving.
Fourteen healthy smokers meeting ICD-10 criteria for tobacco addiction participated in this within-subject sham controlled study. Participants had to abstain from smoking 6 h before the experiment. Effects of high-frequency repetitive TMS (hf rTMS) (10 Hz) for verum (left DLPFC) and sham (vertex) stimulations on cue-induced nicotine craving and resting state EEG delta power were assessed before and three times within 40 min after rTMS.
Both craving (P = 0.046) and EEG delta power (P = 0.048) were significantly lower after verum stimulation compared to sham stimulation across the whole post stimulation time period assessed. However, changes of craving ratings and delta power did not correlate.
Hf rTMS applied to the left DLPFC reduces nicotine craving in short-term abstinent smokers. Changes in delta activity support the idea that stimulation induced effects are mediated by the dopaminergic brain reward system, which presumably plays a prominent, but probably not exclusive, role in this stimulation induced behavioral modulation, making this method a promising smoking cessation treatment candidate.
TMS 作为戒烟治疗具有很大的潜力。然而，TMS 诱导的烟草渴求减少的神经机制尚不清楚。脑电图（EEG）δ频带与多巴胺能大脑奖励系统的活动有关，该系统对尼古丁诱导的作用至关重要，并且在吸烟者中尼古丁摄入后会降低。
本研究旨在探讨高频重复经颅磁刺激（hf rTMS）左背外侧前额叶皮质（DLPFC）对尼古丁剥夺吸烟者的 EEG δ功率变化及其与线索诱导的尼古丁渴求的关系。
14 名符合 ICD-10 烟草成瘾标准的健康吸烟者参加了这项单盲对照研究。参与者必须在实验前 6 小时内戒烟。评估高频重复经颅磁刺激（hf rTMS）（10 Hz）对真（左 DLPFC）和假（顶点）刺激对线索诱导的尼古丁渴求及静息状态 EEG δ功率的影响，在 rTMS 前后和 rTMS 后 40 分钟内三次评估。
与假刺激相比，真刺激后渴求（P = 0.046）和 EEG δ功率（P = 0.048）在整个刺激后时间内均显著降低。然而，渴求评分和δ功率的变化没有相关性。
应用于左 DLPFC 的 hf rTMS 可降低短期戒断吸烟者的尼古丁渴求。δ 活动的变化支持这样一种观点，即刺激诱导的效应是由多巴胺能大脑奖励系统介导的，该系统在这种刺激诱导的行为调节中可能起着突出但可能不是唯一的作用，使这种方法成为一种有前途的戒烟治疗候选方法。
