Li Min, Hou Wenshang, Zhang Xiaowei, Hu Liqin, Tang Zhenyu
Department of Neurology, The Second Affiliated Hospital, School of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Department of Neurology, The Second Affiliated Hospital, School of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Atherosclerosis. 2014 Feb;232(2):265-70. doi: 10.1016/j.atherosclerosis.2013.11.051. Epub 2013 Dec 1.
Hyperuricemia may be associated with an increased risk of stroke, but to date results from prospective studies have been inconsistent. This study aimed to evaluate the association between hyperuricemia and risk of stroke incidence and mortality by performing a meta-analysis.
Studies were identified by searching multiple electronic databases through July 13, 2013, and by reviewing reference lists of obtained articles. Prospective studies reported a multivariate-adjusted estimate, represented as relative risk (RRs) with 95% confidence intervals (CIs) for the association between hyperuricemia and risk of stroke incidence and mortality were eligible. A random-effects model was used to compute the pooled risk estimate.
A total of fourteen articles including results from 15 prospective studies with 22,571 cases of stroke and 1,042,358 participants were included in the meta-analysis. Overall, presence of hyperuricemia was associated with a significantly greater risk of both stroke incidence (RR, 1.22; 95% CI, 1.02-1.46) and mortality (RR, 1.33; 95% CI, 1.24-1.43). In addition, the pooled estimate of multivariate RRs of stroke incidence and mortality were 1.08 (95% CI: 0.85-1.38); 1.26 (95% CI: 1.14-1.40) among men and 1.25 (95% CI: 1.04-1.46); 1.41 (95% CI: 1.31-1.52) among women respectively.
Results from this meta-analysis indicate that hyperuricemia may modestly increase the risks of both stroke incidence and mortality. Future studies should explore whether hyperuricemia is a modifiable risk factor for stroke.
高尿酸血症可能与中风风险增加有关,但迄今为止前瞻性研究的结果并不一致。本研究旨在通过进行荟萃分析来评估高尿酸血症与中风发病率及死亡率风险之间的关联。
通过检索多个电子数据库至2013年7月13日,并查阅所获文章的参考文献列表来确定研究。符合条件的前瞻性研究需报告多变量调整后的估计值,以相对风险(RRs)及95%置信区间(CIs)表示高尿酸血症与中风发病率及死亡率风险之间的关联。采用随机效应模型计算合并风险估计值。
荟萃分析共纳入14篇文章,包括15项前瞻性研究的结果,涉及22,571例中风病例和1,042,358名参与者。总体而言,高尿酸血症的存在与中风发病率(RR,1.22;95%CI,1.02 - 1.46)和死亡率(RR,1.33;95%CI,1.24 - 1.43)的显著更高风险相关。此外,中风发病率和死亡率的多变量RRs合并估计值在男性中分别为1.08(95%CI:0.85 - 1.38);1.26(95%CI:1.14 - 1.40),在女性中分别为1.25(95%CI:1.04 - 1.46);1.41(95%CI:1.31 - 1.52)。
该荟萃分析结果表明,高尿酸血症可能会适度增加中风发病率和死亡率的风险。未来的研究应探讨高尿酸血症是否是中风的一个可改变的风险因素。