Li Chunyan, Sun Jiajia, Wei Qifeng, Yue Jianrong, Wang Xuefei, Zhang Qin, Peng Shiping, Liao Xiujuan, Zeng Hui, Asakawa Tetsuya
Department of Health Management, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, People's Republic of China.
Faculty of Medicine, Macau University of Science and Technology, Macao, People's Republic of China.
Int J Gen Med. 2025 Jan 14;18:165-175. doi: 10.2147/IJGM.S496045. eCollection 2025.
This is a hospital-based, single-center, cross-sectional study to investigate the of hyperuricaemia (HUA) in general adults in Shenzhen, a booming seaside city in the South China.
All health adults (≥18 years old) undergoing health examination from 2020 Oct 1 to 2021 September 30 in a general hospital were enrolled. Their medical records were investigated and analyzed.
Total 4604 participants (2938 males and 1756 females) were included and analyzed. We found that although the participants in Shenzhen were younger than the people included the analogous study in the adjacent cities (total 38.41 ± 10.33 years, 39.11 ± 10.18 in males and 37.24 ± 10.47 in females), the prevalence of HUA reached to amazing 34.7% (43.5% in males and 20.1% in females). Moreover, great HUA-related gender difference was found in terms of age-related variation trends of HUA prevalence ( < 0.001), indices of laboratory examination ( < 0.01) and influence factors ( < 0.001).
These results raise alarm bells for the HUA problem in the booming seaside city with young population like Shenzhen in China (2020-2021). Effective measures are appealed to reduce the high prevalence of HUA of Shenzhen. In addition, during analyses of the data, we found that both the prevalence of HUA and age of the population need to be seriously considered. Accordingly, we propose a more representative index, namely "Prevalence-Age Index (PAI = Prevalence of HUA/Average age)" to be used in the future HUA-related investigations.
这是一项基于医院的单中心横断面研究，旨在调查中国南方蓬勃发展的海滨城市深圳普通成年人高尿酸血症（HUA）的情况。
纳入2020年10月1日至2021年9月30日在一家综合医院接受健康检查的所有健康成年人（≥18岁）。对他们的病历进行调查和分析。
共纳入并分析了4604名参与者（男性2938名，女性1756名）。我们发现，尽管深圳的参与者比邻近城市类似研究中的人群更年轻（总体38.41±10.33岁，男性39.11±10.18岁，女性37.24±10.47岁），但HUA患病率达到了惊人的34.7%（男性为43.5%，女性为20.1%）。此外，在HUA患病率的年龄相关变化趋势（<0.001）、实验室检查指标（<0.01）和影响因素（<0.001）方面发现了显著的HUA相关性别差异。
这些结果为中国深圳这样年轻人口众多的蓬勃发展的海滨城市（2020 - 2021年）的HUA问题敲响了警钟。呼吁采取有效措施降低深圳HUA的高患病率。此外，在数据分析过程中，我们发现HUA患病率和人群年龄都需要认真考虑。因此，我们提出一个更具代表性的指标，即“患病率 - 年龄指数（PAI = HUA患病率/平均年龄）”，以供未来与HUA相关的调查使用。
