Pokryszko-Dragan Anna, Bladowska Joanna, Zimny Anna, Slotwinski Krzysztof, Zagrajek Mieszko, Gruszka Ewa, Bilinska Malgorzata, Sasiadek Marek, Podemski Ryszard
Department of Neurology, Medical University of Wroclaw, Poland.
Department of General Radiology, Interventional Radiology and Neuroradiology, Medical University of Wroclaw, Poland.
J Neurol Sci. 2014 Apr 15;339(1-2):35-40. doi: 10.1016/j.jns.2014.01.013. Epub 2014 Jan 15.
The origin of fatigue in multiple sclerosis (MS) remains unclear. Magnetic resonance spectroscopy (MRS) provides an insight into metabolic properties of the brain.
The aim of the study was to evaluate brain MRS measurements in MS patients, with regard to fatigue and cognition.
The study comprised 32 MS patients and 43 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS) and cognition - using the Brief Repeatable Battery of Neuropsychological Tests (parts of BRBNT). MRS voxels were placed in the parietal white matter (PWM) and the posterior cingulate gyrus (PCG); N-acetyl-aspartate (NAA), choline (Cho) and myoinositol (mI) to creatine (Cr) ratios were determined. Relationships were searched between MRS measurements and fatigue as well as BRBNT results.
MS patients in comparison with controls showed decreased NAA/Cr and increased mI/Cr ratios in PCG and PWM, respectively. No significant relationships between MRS parameters and fatigue measures, BRBNT results or MS-related variables were found.
The decrease of NAA and increase of mI within white and gray matters in MS patients do not show a significant relationship with cognitive performance or fatigue.
多发性硬化症（MS）中疲劳的起源仍不清楚。磁共振波谱（MRS）可深入了解大脑的代谢特性。
本研究旨在评估MS患者大脑的MRS测量结果与疲劳和认知的关系。
该研究纳入了32例MS患者和43名对照者。使用疲劳严重程度量表（FSS）和改良疲劳影响量表（MFIS）评估疲劳，使用简短可重复神经心理测试电池（BRBNT的部分内容）评估认知。将MRS体素置于顶叶白质（PWM）和后扣带回（PCG）；测定N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌醇（mI）与肌酸（Cr）的比值。研究MRS测量结果与疲劳以及BRBNT结果之间的关系。
与对照组相比，MS患者PCG和PWM中的NAA/Cr比值降低，mI/Cr比值分别升高。未发现MRS参数与疲劳测量、BRBNT结果或MS相关变量之间存在显著关系。
MS患者白质和灰质中NAA的降低和mI的升高与认知表现或疲劳无显著关系。
