Smadja David M
Stem Cell Res Ther. 2014 Jan 27;5(1):16. doi: 10.1186/scrt405.
Endothelial progenitor cell therapy and stem cell therapy have been proposed in regeneration of acute myocardial infarction (AMI). In the previous issue of Stem Cell Research & Therapy, Lamirault and colleagues described a strong analysis of progenitors in blood and bone marrow of patients collected after AMI, and correlated these levels to bone marrow mononuclear cell (BM-MNC) therapy efficacy and smoking status. The main results are that BM-MNCs can override smoking alteration in endothelial lineage and confirm that endothelial progenitor cells are probably not by themselves the active component of BM-MNC in AMI. This paper allows one to better appreciate the cellular complexity of cell therapy approach in AMI.
内皮祖细胞疗法和干细胞疗法已被提出用于急性心肌梗死（AMI）的再生治疗。在上一期的《干细胞研究与治疗》中，拉米罗及其同事对急性心肌梗死后收集的患者血液和骨髓中的祖细胞进行了深入分析，并将这些水平与骨髓单个核细胞（BM-MNC）治疗效果及吸烟状况相关联。主要结果是，BM-MNCs可以克服吸烟对内皮谱系的影响，并证实内皮祖细胞本身可能不是AMI中BM-MNC的活性成分。本文有助于人们更好地理解AMI细胞治疗方法的细胞复杂性。
