Galanin: a potent modulator of excitatory neurotransmission in the human urinary bladder.

作者信息

Maggi C A, Santicioli P, Patacchini R, Turini D, Barbanti G, Beneforti P, Giuliani S, Meli A

机构信息

Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.

出版信息

Eur J Pharmacol. 1987 Nov 3;143(1):135-7. doi: 10.1016/0014-2999(87)90744-8.

Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. GAL had an ED50 of 2 nM for the inhibition. The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. These data suggest a possible neuromodulator role of GAL in the human urinary bladder.