Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zürich, Schmelzbergstrasse 7, Zürich CH-8092, Switzerland.
Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zürich, Schmelzbergstrasse 7, Zürich CH-8092, Switzerland.
Curr Opin Biotechnol. 2014 Apr;26:141-7. doi: 10.1016/j.copbio.2013.12.012. Epub 2014 Jan 28.
Initial neonatal gut colonization is a crucial stage for developing a healthy physiology, beneficially influenced by breast-feeding. Breast milk has been shown not only to provide nutrients and bioactive immunological compounds, but also commensal bacteria, including gut-associated anaerobic bacteria such as Bifidobacterium species. Infant formulas are increasingly supplemented with probiotic bacteria despite uncertainties regarding their efficacy, and lack of mechanistic understanding. Breast milk may be a valuable source of such bacteria which, upon validation of their mechanism of action, might open a window of opportunity for developing probiotic-supplemented infant formula with proven efficacy.
初始新生儿肠道定植是形成健康生理机能的关键阶段，而母乳喂养对此有有益影响。事实表明，母乳不仅提供营养成分和具有生物活性的免疫化合物，还提供共生菌，包括肠道相关的厌氧菌，如双歧杆菌属。尽管对于益生菌的功效存在不确定性，且缺乏对其作用机制的了解，婴儿配方奶粉仍在日益添加益生菌。母乳可能是此类细菌的宝贵来源，如果验证其作用机制，可能会为开发具有经过验证功效的益生菌补充婴儿配方奶粉提供机会。
