Ruxton Carrie Helen Stevenson, Kajita Chiyuki, Rocca Paola, Pot Bruno
Nutrition Communications, Cupar, UK.
Yakult Europe BV, Almere, Netherlands.
Gut Microbiome (Camb). 2023 Mar 27;4:e6. doi: 10.1017/gmb.2023.4. eCollection 2023.
The 10th International Yakult Symposium was held in Milan, Italy, on 13-14 October 2022. Two keynote lectures covered the crewed journey to space and its implications for the human microbiome, and how current regulatory systems can be adapted and updated to ensure the safety of microorganisms used as probiotics or food processing ingredients. The remaining lectures were split into sections entitled "Chances" and "Challenges." The "Chances" section explored opportunities for the science of probiotics and fermented foods to contribute to diverse areas of health such as irritable bowel syndrome, major depression, Parkinson's disease, immune dysfunction, infant colic, intensive care, respiratory infections, and promoting healthy longevity. The "Challenges" section included selecting appropriate clinical trial participants and methodologies to minimise heterogeneity in responses, how to view probiotics in the context of One Health, adapting regulatory frameworks, and understanding how substances of bacterial origin can cross the blood-brain barrier. The symposium provided evidence from cutting-edge research that gut eubiosis is vital for human health and, like space, the microbiota deserves further exploration of its vast potential.
第十届国际养乐多研讨会于2022年10月13日至14日在意大利米兰举行。两场主题演讲分别涉及载人太空之旅及其对人类微生物群的影响，以及当前的监管系统如何调整和更新，以确保用作益生菌或食品加工成分的微生物的安全性。其余演讲分为“机遇”和“挑战”两个部分。“机遇”部分探讨了益生菌和发酵食品科学在促进多种健康领域（如肠易激综合征、重度抑郁症、帕金森病、免疫功能障碍、婴儿腹绞痛、重症监护、呼吸道感染以及促进健康长寿）中发挥作用的机会。“挑战”部分包括选择合适的临床试验参与者和方法以尽量减少反应的异质性、如何在“同一健康”背景下看待益生菌、调整监管框架以及了解细菌来源的物质如何穿过血脑屏障。该研讨会提供了前沿研究的证据，表明肠道微生态平衡对人类健康至关重要，而且与太空一样，微生物群的巨大潜力值得进一步探索。
