Department of Physiology, Wroclaw Medical University, Wroclaw, Poland.
Cardiol J. 2013;20(5):453-63. doi: 10.5603/CJ.2013.0130.
Diabetes mellitus (DM) is a disease of increasing incidence and prevalence. Arterial baroreceptors are stretch-sensitive receptors, which in a reflex manner are involved in the homeostatic control of arterial blood pressure. Diabetic subjects have depressed baroreflex sensitivity (BRS), although the exact pathomechanisms are unclear. In this review, we discuss the features, clinicaland prognostic implications of reduced BRS for diabetic patients and the potential involvement of cardiovascular autonomic neuropathy and atherosclerosis. Finally, we demonstrate evidence on interventions (e.g. pioglitazone, alpha-lipoic acid, leptin, fluvastatin, physicaltraining etc.) which could improve BRS and ameliorate cardiovascular autonomic dysfunction in diabetic patients.
糖尿病（DM）是一种发病率和患病率不断增加的疾病。动脉压力感受器是一种张力敏感感受器，它以反射的方式参与动脉血压的稳态控制。糖尿病患者的压力反射敏感性（BRS）降低，尽管确切的发病机制尚不清楚。在这篇综述中，我们讨论了降低 BRS 对糖尿病患者的特征、临床和预后意义，以及心血管自主神经病变和动脉粥样硬化的潜在参与。最后，我们展示了一些干预措施（如吡格列酮、α-硫辛酸、瘦素、氟伐他汀、体育锻炼等）的证据，这些措施可以改善糖尿病患者的 BRS 并改善心血管自主神经功能障碍。
