伊朗人群凝血因子 VII R353Q 多态性与冠状动脉疾病严重程度的关系。

Association between R353Q polymorphism for coagulative factor VII and severity of coronary artery disease in Iranian population.

机构信息

Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Cardiol J. 2013;20(5):533-8. doi: 10.5603/CJ.2013.0139.

DOI:10.5603/CJ.2013.0139

PMID:24469878

Abstract

BACKGROUND

Recent research has supported the central role of coagulative factors in advancing atherosclerosis and causing coronary artery disease (CAD). The present study, for the first time, aimed to clarify the relationship between R353Q polymorphism for factor VII and the occurrence and severity of CAD in a large sample of Iranian population.

METHODS

Nine hundred and nineteen consecutive patients with suspected CAD, who candidated for coronary angiography in the Tehran Heart Center between January 2006 and March 2007, were examined. The number of diseased coronary vessels was determined, and the severity of CAD was assessed by the Gensini score. Genotyping was done via the PCR-RFLP method.

RESULTS

The frequency of Q and R alleles was 74.1% and 25.9% in the patients with CADand 75.2% and 24.8% in those without CAD, with an insignificant difference (p = 0.625). The frequency of Q allele in the patients with single-vessel, two-vessel, and three-vessel diseases was 72.8%, 71.5%, and 76.4%, respectively; the difference was also insignificant (p = 0.379). No relationship was observed between the distribution of the genotypes and the number of the involved coronary vessels. The average of the Gensini score was 43.39 ± 46.18 in the patients with QQ genotype, 38.87 ± 42.89 in those with QR genotype, and 55.61 ± 53.80 in the ones with RR genotype, with the difference not constituting any statistical significance (p = 0.084).

CONCLUSIONS

The results suggest no association between R353Q polymorphism for factor VII and the presence or progression of CAD in the Iranian population.

摘要

背景

最近的研究支持凝血因子在促进动脉粥样硬化和导致冠心病（CAD）方面的核心作用。本研究首次旨在澄清因子 VII 的 R353Q 多态性与伊朗人群中 CAD 的发生和严重程度之间的关系。

方法

2006 年 1 月至 2007 年 3 月，在德黑兰心脏中心连续检查了 919 例疑似 CAD 的连续患者，进行冠状动脉造影。确定了病变冠状动脉的数量，并通过 Gensini 评分评估 CAD 的严重程度。通过 PCR-RFLP 方法进行基因分型。

结果

CAD 患者和 CAD 患者的 Q 和 R 等位基因频率分别为 74.1%和 25.9%和 75.2%和 24.8%，无显著性差异（p=0.625）。单支、双支和三支病变患者的 Q 等位基因频率分别为 72.8%、71.5%和 76.4%，差异无统计学意义（p=0.379）。基因型分布与受累冠状动脉数量之间无相关性。QQ 基因型患者的 Gensini 评分平均为 43.39±46.18，QR 基因型患者为 38.87±42.89，RR 基因型患者为 55.61±53.80，差异无统计学意义（p=0.084）。