Vladimirskaya E B
Research Institute of Pediatrics, USSR Academy of Medical Sciences, Moscow.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(4):542-8.
A simple method is described by which the degree to which a bone marrow aspirate is diluted with peripheral blood, the admixture of peripheral blood leukocytes in the aspirate, and the true cellularity of bone marrow at the aspiration site can be estimated quantitatively. A highly significant correlation is shown to exist between the true bone marrow cellularity and the number of hemopoietic cells in the bone marrow aspirate. This correlation can be described by an exponential regression equation (r = 0.6997; p less than or equal to 0.001). The degree of bone marrow dilution with peripheral blood does not depend on the initial bone marrow cellularity and is devoid of diagnostic value. It fluctuates over a wide range (1.2- to 6.3-fold). The admixture of peripheral blood leukocytes has been found to be small (0.05%-9.7%) in most cases studied and much higher in those cases where the cellularity is low while the dilution is high.
本文描述了一种简单的方法，通过该方法可以定量估计骨髓穿刺液被外周血稀释的程度、穿刺液中外周血白细胞的混合情况以及穿刺部位骨髓的真实细胞密度。结果显示，骨髓真实细胞密度与骨髓穿刺液中造血细胞数量之间存在高度显著的相关性。这种相关性可用指数回归方程描述（r = 0.6997；p≤0.001）。外周血对骨髓的稀释程度不取决于初始骨髓细胞密度，且无诊断价值。其波动范围很广（1.2至6.3倍）。在大多数研究病例中，外周血白细胞的混合比例较小（0.05%-9.7%），而在细胞密度低且稀释度高的病例中则要高得多。
