波生坦与西地那非治疗人类免疫缺陷病毒相关肺动脉高压
Bosentan and sildenafil in the treatment of HIV-associated pulmonary hypertension.
作者信息
Chinello Pierangelo, Cicalini Stefania, Cortese Andrea, Cicini Maria Paola, Petrosillo Nicola
机构信息
Second Infectious Diseases Unit, L. Spallanzani National Institute for Infectious Diseases, Rome;
U.O. Diagnostica per Immagini, S. Camillo-Forlanini Hospital, Rome;
出版信息
Infect Dis Rep. 2011 Nov 22;3(2):e14. doi: 10.4081/idr.2011.e14. eCollection 2011 Sep 7.
We present the case of an HIV/HCV-coinfected patient with HIV-related pulmonary hypertension (HRPH) who experienced a good clinical and functional response to bosentan, with a subsequent switch to oral sildenafil due to increased transaminase levels. Bosentan resulted less handy in this case, probably due to both side effects and co-morbidities.
我们报告了一例合并感染HIV/HCV且患有HIV相关肺动脉高压（HRPH）的患者，该患者使用波生坦后临床及功能方面均有良好反应，随后因转氨酶水平升高改用口服西地那非。在该病例中，波生坦使用起来不太方便，这可能是由副作用和合并症共同导致的。
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