Alvarez-Uria Gerardo, Naik Praveen K, Midde Manoranjan, Kannan Shanmugamari, Reddy Raghuprakash
Department of Infectious Diseases, and.
Department of Microbiology, Rural Development Trust Hospital, Bathalapalli, Anantapur district, AP, India.
Infect Dis Rep. 2012 Jan 4;4(1):e6. doi: 10.4081/idr.2012.e6. eCollection 2012 Jan 2.
With the implementation of 2010 World Health Organization guidelines, the number of infants from developing countries who will initiate antiretroviral therapy (ART) will increase considerably. In this study we describe the HIV antibody tests of 14 HIV infected children who initiated ART at age less than one year in a rural setting of India. The HIV rapid test was negative in seven and indeterminate in two cases, whereas the HIV enzyme-linked immunosorbent assay (ELISA) antibody test was negative in three and indeterminate in one case. In one child who had both negative HIV rapid test and ELISA initially, HIV serology turned positive after having a virological failure to ART, suggesting the possibility of utilizing HIV serology for monitoring ART effectiveness in children who experience HIV seroreversion. In conclusion, HIV seroreversion of children with early initiation of ART is common and should be considered for avoiding misdiagnosis of HIV infection.
随着2010年世界卫生组织指南的实施，来自发展中国家开始接受抗逆转录病毒疗法（ART）的婴儿数量将大幅增加。在本研究中，我们描述了14名在印度农村地区年龄小于1岁时开始接受ART的HIV感染儿童的HIV抗体检测情况。7名儿童的HIV快速检测结果为阴性，2例结果不确定；而HIV酶联免疫吸附测定（ELISA）抗体检测中，3名儿童结果为阴性，1例结果不确定。在1名最初HIV快速检测和ELISA均为阴性的儿童中，在ART出现病毒学失败后HIV血清学转为阳性，这表明在经历HIV血清学逆转的儿童中利用HIV血清学监测ART疗效具有可能性。总之，早期开始接受ART的儿童出现HIV血清学逆转很常见，应予以考虑以避免HIV感染的误诊。
