Zhou Li, Saksena Nitin K
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney , Australia.
Infect Dis Rep. 2013 Jun 6;5(Suppl 1):e8. doi: 10.4081/idr.2013.s1.e8.
Human immunodeficiency virus type 1 is associated with the development of neurocognitive disorders in many infected individuals, including a broad spectrum of motor impairments and cognitive deficits. Despite extensive research, the pathogenesis of HIV-associated neurocognitive disorders (HAND) is still not clear. This review provides a comprehensive view of HAND, including HIV neuroinvasion, HAND diagnosis and different level of disturbances, influence of highly-active antiretroviral therapy to HIV-associated dementia (HAD), possible pathogenesis of HAD, etc. Together, this review will give a thorough and clear understanding of HAND, especially HAD, which will be vital for future research, diagnosis and treatment.
1型人类免疫缺陷病毒与许多受感染个体的神经认知障碍的发展有关，包括广泛的运动障碍和认知缺陷。尽管进行了广泛的研究，但HIV相关神经认知障碍（HAND）的发病机制仍不清楚。本综述全面介绍了HAND，包括HIV神经侵袭、HAND诊断和不同程度的功能障碍、高效抗逆转录病毒疗法对HIV相关痴呆（HAD）的影响、HAD可能的发病机制等。总之，本综述将使人们对HAND，尤其是HAD有全面而清晰的了解，这对未来的研究、诊断和治疗至关重要。
