Liu Bianjiang, Song Zhen, Xu Aiming, Su Shifeng, Wang Zengjun, Yin Changjun
State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Med Hypotheses. 2014 Mar;82(3):338-40. doi: 10.1016/j.mehy.2013.12.022. Epub 2014 Jan 14.
Seminal vesiculitis is the common disease of male urogenital system. However, the pathogenesis of seminal vesiculitis remains unclear. Semenogelin I (Sg I) is mainly synthesized and secreted by seminal vesicle and has antibacterial activity. We thus postulate that Sg I plays an important role during the occurrence and development of seminal vesiculitis. In the present study, we analyzed the expression of Sg I in normal seminal vesicle tissues and seminal vesiculitis tissues through immunohistochemistry. The results showed down-regulated expression of clusterin at protein level in seminal vesiculitis tissues compared with normal seminal vesicle tissues. Our preliminary data suggest that the abnormal expression of clusterin is closely related to seminal vesiculitis. Downregulation of Sg I expression may weaken the antibacterial activity of the seminal vesicle and then induce the occurrence of disease. This is the first study to focus on the relationship between Sg I and human seminal vesiculitis.
精囊炎是男性泌尿生殖系统的常见疾病。然而，精囊炎的发病机制仍不清楚。精囊蛋白I（Sg I）主要由精囊合成和分泌，具有抗菌活性。因此，我们推测Sg I在精囊炎的发生和发展过程中起重要作用。在本研究中，我们通过免疫组织化学分析了Sg I在正常精囊组织和精囊炎组织中的表达。结果显示，与正常精囊组织相比，精囊炎组织中簇集素蛋白水平表达下调。我们的初步数据表明，簇集素的异常表达与精囊炎密切相关。Sg I表达下调可能会削弱精囊的抗菌活性，进而诱发疾病的发生。这是第一项关注Sg I与人类精囊炎关系的研究。
