儿童闭塞性细支气管炎的 CT 密度容积测定：与临床评分和肺功能测试结果的相关性。
CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results.
机构信息
Santa Casa Sisters of Mercy Hospital Complex in Porto Alegre, Porto Alegre, Brazil.
Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
出版信息
J Bras Pneumol. 2013 Nov-Dec;39(6):701-10. doi: 10.1590/S1806-37132013000600009.
OBJECTIVE
To determine whether air trapping (expressed as the percentage of air trapping relative to total lung volume [AT%]) correlates with clinical and functional parameters in children with obliterative bronchiolitis (OB).
METHODS
CT scans of 19 children with OB were post-processed for AT% quantification with the use of a fixed threshold of -950 HU (AT%950) and of thresholds selected with the aid of density masks (AT%DM). Patients were divided into three groups by AT% severity. We examined AT% correlations with oxygen saturation (SO2) at rest, six-minute walk distance (6MWD), minimum SO2 during the six-minute walk test (6MWT_SO2), FVC, FEV1, FEV1/FVC, and clinical parameters.
RESULTS
The 6MWD was longer in the patients with larger normal lung volumes (r = 0.53). We found that AT%950 showed significant correlations (before and after the exclusion of outliers, respectively) with the clinical score (r = 0.72; 0.80), FVC (r = 0.24; 0.59), FEV1 (r = -0.58; -0.67), and FEV1/FVC (r = -0.53; r = -0.62), as did AT%DM with the clinical score (r = 0.58; r = 0.63), SO2 at rest (r = -0.40; r = -0.61), 6MWT_SO2 (r = -0.24; r = -0.55), FVC (r = -0.44; r = -0.80), FEV1 (r = -0.65; r = -0.71), and FEV1/FVC (r = -0.41; r = -0.52).
CONCLUSIONS
Our results show that AT% correlates significantly with clinical scores and pulmonary function test results in children with OB.
目的
确定空气潴留（以空气潴留相对于全肺容积的百分比[AT%]表示）是否与闭塞性细支气管炎（OB）患儿的临床和功能参数相关。
方法
对 19 例 OB 患儿的 CT 扫描进行后处理，使用-950 HU 的固定阈值（AT%950）和密度掩模辅助选择的阈值（AT%DM）来定量 AT%。根据 AT%严重程度将患者分为三组。我们检查了 AT%与静息时血氧饱和度（SO2）、6 分钟步行距离（6MWD）、6 分钟步行试验期间最低 SO2（6MWT_SO2）、FVC、FEV1、FEV1/FVC 和临床参数的相关性。
结果
具有较大正常肺容积的患者 6MWD 更长（r = 0.53）。我们发现 AT%950 与临床评分（分别在排除异常值之前和之后，r = 0.72；0.80）、FVC（r = 0.24；0.59）、FEV1（r = -0.58；-0.67）和 FEV1/FVC（r = -0.53；r = -0.62）具有显著相关性，AT%DM 与临床评分（r = 0.58；r = 0.63）、静息时 SO2（r = -0.40；r = -0.61）、6MWT_SO2（r = -0.24；r = -0.55）、FVC（r = -0.44；r = -0.80）、FEV1（r = -0.65；r = -0.71）和 FEV1/FVC（r = -0.41；r = -0.52）具有显著相关性。
结论
我们的结果表明，AT%与 OB 患儿的临床评分和肺功能测试结果显著相关。
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