Mattiello Rita, Sarria Edgar E, Stein Ricardo, Fischer Gilberto Bueno, Mocelin Helena Teresinha, Barreto Sergio Saldanha Menna, Lima João Antônio Bonfadini, Brandenburg Diego
Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
J Pediatr (Rio J). 2008 Jul-Aug;84(4):337-43. doi: 10.2223/JPED.1807.
To assess functional capacity during exercise in children and adolescents with post-infectious bronchiolitis obliterans (PIBO).
20 children with PIBO, aged 8-16 years old, and in follow-up at an outpatient clinic carried out cardiopulmonary exercise testing (CPET), a 6-minute walk test (6MWT) and pulmonary function tests (PFT), according to American Thoracic Society (ATS), European Respiratory Society (ERS) and American College of Chest Physicians (ACCP) guidelines. Results were expressed as percentages of predicted reference values: Armstrong's for CPET, Geiger's for 6MWT, Knudson's for spirometry, and Zapletal's for plethysmography.
Mean age (+/- SD) was 11.4+/-2.2 years; 70% were boys; mean weight: 36.8+/-12.3 kg; mean height: 143.8+/-15.2 cm. When compared to reference values, PFT detected lower airflows (spirometry) and higher volumes (plethysmography). Eleven patients had reduced peak VO2 values in CPET (< 84% predicted). The mean distance walked (6MWT) was 77.0+/-15.7% of predicted (512+/-102 m). Peak VO2 was not correlated with 6MWT, but it was correlated with FVC (L) (r = 0.90/p = 0.00), with FEV1 (L) (r = 0.86/p = 0.00) and with RV/TLC, both in absolute values (r = -0.71/p = 0.02) and as percentages of predicted values (r = -0.63/p = 0.00).
The majority of these post-infectious bronchiolitis obliterans patients exhibited reduced functional capacity, exhibited during both CPET and the 6MWT. Due to its greater feasibility, 6MWT could be an alternative where CPET is not available.
评估感染后闭塞性细支气管炎（PIBO）患儿及青少年运动时的功能能力。
20名年龄在8至16岁、在门诊接受随访的PIBO患儿，根据美国胸科学会（ATS）、欧洲呼吸学会（ERS）和美国胸科医师学会（ACCP）的指南，进行了心肺运动试验（CPET）、6分钟步行试验（6MWT）和肺功能测试（PFT）。结果以预测参考值的百分比表示：CPET采用阿姆斯特朗的标准，6MWT采用盖格的标准，肺活量测定采用努德森的标准，体积描记法采用扎普莱塔尔的标准。
平均年龄（±标准差）为11.4±2.2岁；70%为男孩；平均体重：36.8±12.3千克；平均身高：143.8±15.2厘米。与参考值相比，PFT检测到气流较低（肺活量测定）和肺容积较高（体积描记法）。11名患者在CPET中的峰值VO2值降低（<预测值的84%）。平均步行距离（6MWT）为预测值的77.0±15.7%（512±102米）。峰值VO2与6MWT无关，但与FVC（升）相关（r = 0.90/p = 0.00），与FEV1（升）相关（r = 0.86/p = 0.00），与RV/TLC相关，包括绝对值（r = -0.71/p = 0.02）和预测值的百分比（r = -0.63/p = 0.00）。
这些感染后闭塞性细支气管炎患者中的大多数在CPET和6MWT中均表现出功能能力下降。由于6MWT的可行性更高，在无法进行CPET的情况下，6MWT可以作为一种替代方法。
