da Costa Neto Sócrates Fraga, Alves Vinicius Menezes Tunholi, Alves Victor Menezes Tunholi, Garcia Juberlan Silva, dos Santos Marcos Antônio José, Nogueira Vivian de Assunção, Brito Marilene de Farias, Gentile Rosana, Pinheiro Jairo
Curso de Pós-graduação em Ciências Veterinárias, Departamento de Parasitologia Animal, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro - UFRRJ, SeropédicaRJ, Brasil, Curso de Pós-graduação em Ciências Veterinárias, Departamento de Parasitologia Animal, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro - UFRRJ, Seropédica, RJ, Brasil.
Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz - IOC, Fundação Oswaldo Cruz - Fiocruz, Rio de JaneiroRJ, Brasil, Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz - IOC, Fundação Oswaldo Cruz - Fiocruz, Rio de Janeiro, RJ, Brasil.
Rev Bras Parasitol Vet. 2013 Oct-Dec;22(4):519-24. doi: 10.1590/S1984-29612013000400011.
The South American water rat Nectomys squamipes is a wild mammal reservoir of Schistosoma mansoni in Brazil. In the present study, wild rodents were collected in the field and categorized into two groups: infected and uninfected by S. mansoni. Blood was collected to analyze changes in the serum glucose level (mg/dL) and liver fragments were used to determine the hepatic glycogen content (mg of glucose/g tissue). The histological examination showed inflammatory granulomatous lesions in different phases of development in the liver of rodents naturally infected with S. mansoni, in some cases with total or partial occlusion of the vascular lumen. Early lesions were characterized by the presence of inflammatory infiltrate around morphologically intact recently deposited eggs. Despite the significance of these histological lesions, the biochemical changes differed in extent. N. squamipes naturally infected by S. mansoni showed no variation in hepatic glycogen reserves. These findings were accompanied by a significant increase in plasma glucose contents, probably as a consequence of amino acids deamination, which are degraded, resulting in the formation of intermediates used as precursors for the glucose formation, without compromising the reserves of liver glycogen. In the wild, naturally infected N. squamipes can maintain S. mansoni infections without undergoing alterations in its carbohydrate metabolism, which minimizes the deleterious effects of S. mansoni.
南美水鼠（Nectomys squamipes）是巴西曼氏血吸虫的野生哺乳动物宿主。在本研究中，在野外收集野生啮齿动物，并将其分为两组：感染曼氏血吸虫和未感染曼氏血吸虫的。采集血液以分析血清葡萄糖水平（mg/dL）的变化，并使用肝脏碎片来确定肝糖原含量（葡萄糖mg/克组织）。组织学检查显示，自然感染曼氏血吸虫的啮齿动物肝脏中存在处于不同发育阶段的炎性肉芽肿病变，在某些情况下血管腔完全或部分闭塞。早期病变的特征是在形态完整的近期沉积虫卵周围存在炎性浸润。尽管这些组织学病变具有重要意义，但生化变化的程度有所不同。自然感染曼氏血吸虫的南美水鼠肝糖原储备没有变化。这些发现伴随着血浆葡萄糖含量的显著增加，这可能是氨基酸脱氨的结果，氨基酸被降解，导致形成用作葡萄糖形成前体的中间体，而不会损害肝糖原储备。在野外，自然感染曼氏血吸虫的南美水鼠可以维持曼氏血吸虫感染，而其碳水化合物代谢不会发生改变，这将曼氏血吸虫的有害影响降至最低。
