University of Pittsburgh Voice Center, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Laryngoscope. 2014 Apr;124(4):921-7. doi: 10.1002/lary.23691. Epub 2014 Jan 28.
OBJECTIVES/HYPOTHESIS: Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation. Our objective was to examine laryngeal secretion cytokine inflammatory profile changes associated with corticosteroid treatment in a human phonotrauma model.
Prospective, individual, randomized, double-blinded, controlled trial.
Participants included 10 healthy females who were randomized to either treatment with oral hydrocortisone or placebo, each given in three doses over 20 hours after the experimental induction of acute phonotrauma. Cytokines associated with inflammation and healing (interleukin [IL]-1β, IL-6, IL-10) were measured in laryngeal secretions before and after vocal loading and at 4 and 20 hours after treatment.
Proinflammatory mediators IL-1β and IL-6 were doubled in the controls versus the steroid treatment group at 21 hours following induction of acute vocal fold inflammation. Anti-inflammatory cytokine IL-10 showed a 6.3-fold increase in the steroid treatment group versus the controls, indicating anti-inflammatory modulation by steroid treatment.
This study provides biologic evidence supporting the use of steroids for acute vocal fold inflammation associated with phonotrauma.
1b.
目的/假设：尽管没有证据表明类固醇对声带炎症有影响，但类固醇仍被用于治疗歌唱家及其他个体的喉炎。我们的目的是在人类嗓音创伤模型中，研究与皮质类固醇治疗相关的喉分泌物细胞因子炎症特征变化。
前瞻性、个体、随机、双盲、对照试验。
参与者包括 10 名健康女性，随机分为皮质醇治疗组或安慰剂组，在急性嗓音创伤实验诱导后 20 小时内，分别给予 3 次口服氢可体松或安慰剂。在发声负荷前后和治疗后 4 小时和 20 小时，测量与炎症和愈合相关的细胞因子（白细胞介素[IL]-1β、IL-6、IL-10）。
与皮质醇治疗组相比，对照组在急性声带炎症诱导后 21 小时，促炎介质 IL-1β 和 IL-6 增加了一倍。皮质醇治疗组抗炎细胞因子 IL-10 增加了 6.3 倍，表明皮质醇治疗具有抗炎调节作用。
本研究提供了生物学证据，支持皮质类固醇治疗与嗓音创伤相关的急性声带炎症。
1b。
