Kharalkar Nachiket M, Bauserman Steven C, Valvano Jonathan W
J Biomech Eng. 2014 Jan 1. doi: 10.1115/1.4026559.
Effect of formalin fixation on thermal conductivity of the biological tissues is presented. A self-heated thermistor probe was used to measure the tissue thermal conductivity. The thermal conductivity of muscle and fatty tissue samples was measured before the formalin fixation and then 27 hours after formalin fixation. The results indicate that the formalin fixation does not cause a significant change in the tissue thermal conductivity of muscle and fatty tissues. In the clinical setting, tissues removed surgically are often fixed in formalin for subsequent pathological analysis. These results suggest that, in terms of thermal properties, it is equally appropriate to perform in vitro studies in either fresh tissue or formalin-fixed tissue.
本文介绍了福尔马林固定对生物组织热导率的影响。使用自热式热敏电阻探头测量组织热导率。在福尔马林固定前以及固定27小时后测量肌肉和脂肪组织样本的热导率。结果表明，福尔马林固定不会导致肌肉和脂肪组织的组织热导率发生显著变化。在临床环境中，手术切除的组织通常用福尔马林固定以便后续进行病理分析。这些结果表明，就热特性而言，在新鲜组织或福尔马林固定组织中进行体外研究同样合适。
