School of Public Health, Guangxi Medical University, Nanning, People's Republic of China.
Pediatr Blood Cancer. 2014 May;61(5):771-7. doi: 10.1002/pbc.24924. Epub 2014 Jan 29.
Quinone oxidoreductase (NQO1) C609T polymorphisms have been implicated in acute myeloblastic leukemia (AML) risk, but previously published studies are inconsistent and recent meta-analyses have not been adequate. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. The quality of studies was evaluated by using the Newcastle-Ottawa Scale (NOS). Crude ORs with 95% CIs were used to assess the strength of association between the NQO1 C609T polymorphisms and AML risk. A total of 14 studies including 2,245 cases and 3,310 controls were involved in this meta-analysis. Overall, significantly elevated AML risk was associated with NQO1 C609T variant genotypes when all studies were pooled into the meta-analysis (TT vs. CC: OR = 1.44, 95% CI = 1.15-1.81; dominant model: OR = 1.35, 95% CI = 1.09-1.68). In the subgroup analysis by ethnicity, significantly increased risks were found for Asians (OR = 1.47, 95% CI = 1.13-1.93, P = 0.005, I(2) = 48.4%, P = 0.071 for heterogeneity). When stratified by studies of adults or children, statistically significantly elevated risks were found among adults (OR = 1.37, 95% CI = 1.06-1.76, P = 0.017, I(2) = 42.2%, P = 0.097 for heterogeneity). The accumulated evidence indicates that NQO1 C609T seems to confer a risk factor for AML among Asians and adults. Significant between-study heterogeneity was observed, thus more studies based on larger case-control population are required to further evaluate the role of NQO1 C609T polymorphism in AML.
醌氧化还原酶（NQO1）C609T 多态性与急性髓细胞性白血病（AML）风险相关，但先前发表的研究结果并不一致，且最近的meta 分析也不充分。为了更准确地评估这种关系，进行了一项meta 分析。检索了 Medline、PubMed、Embase 和 Web of Science。使用 Newcastle-Ottawa 量表（NOS）评估研究质量。使用粗比值比（OR）和 95%置信区间（CI）来评估 NQO1 C609T 多态性与 AML 风险之间的关联强度。这项 meta 分析共纳入了 14 项研究，包括 2245 例病例和 3310 例对照。总体而言，当所有研究纳入meta 分析时，NQO1 C609T 变异基因型与 AML 风险显著相关（TT 与 CC：OR = 1.44，95%CI = 1.15-1.81；显性模型：OR = 1.35，95%CI = 1.09-1.68）。按种族亚组分析，亚洲人群的风险显著增加（OR = 1.47，95%CI = 1.13-1.93，P = 0.005，I² = 48.4%，P = 0.071 表示异质性）。按成人或儿童研究分层，成人中发现的风险显著增加（OR = 1.37，95%CI = 1.06-1.76，P = 0.017，I² = 42.2%，P = 0.097 表示异质性）。累积证据表明，NQO1 C609T 似乎是亚洲人和成年人中 AML 的危险因素。观察到研究之间存在显著的异质性，因此需要更多基于更大病例对照人群的研究来进一步评估 NQO1 C609T 多态性在 AML 中的作用。
