Sun Zihan, Cui Yuling, Pei Jing, Fan Zhiqiang
Department of Laboratory Diagnosis, General Hospital of Jinan Military Region, 25 Shifan Road, Tianqiao District, Jinan, 250031, Shandong, China.
Tumour Biol. 2014 Aug;35(8):7993-8. doi: 10.1007/s13277-014-2051-5. Epub 2014 May 17.
Published studies on the association between NQO1 C609T polymorphism and prostate cancer risk have yielded conflicting results. Thus, a systemic review and meta-analysis of published studies were performed to assess the possible association. All eligible studies of NQO1 C609T polymorphism and prostate cancer risk were collected from the PubMed and the Cochrane Library. Statistical analyses were performed by Review Manage 5.0 and Stata 11.0. A total of 6 available studies were considered in the present meta-analysis, with 717 cases and 1,794 controls. When all groups were pooled, there was no evidence that NQO1 C609T had significant association with prostate cancer under additive, recessive, dominant, and allelic models. When stratifying for the race, our analysis suggested that NQO1 C609T was associated with prostate cancer risk in Asians when using dominant (TT + CT vs CC: OR = 1.419, 95 % CI = 1.053 - 1.913, P = 0.021) and allelic models (OR = 1.337, 95 % CI = 1.014 - 1.763, P = 0.040) to analyze the data. However, no significant associations were found in Caucasians. This meta-analysis suggested that NQO1 C609T polymorphism most likely contributes to increased susceptibility to prostate cancer in the Asians. Further large-scale and well-designed case-control studies are necessary to validate the risk identified in the present meta-analysis.
关于NQO1基因C609T多态性与前列腺癌风险之间关联的已发表研究结果相互矛盾。因此，我们进行了一项已发表研究的系统评价和荟萃分析，以评估可能存在的关联。我们从PubMed和Cochrane图书馆收集了所有关于NQO1基因C609T多态性与前列腺癌风险的符合条件的研究。使用Review Manage 5.0和Stata 11.0进行统计分析。本荟萃分析共纳入6项可用研究，包括717例病例和1794例对照。当合并所有组时，没有证据表明在加性、隐性、显性和等位基因模型下，NQO1基因C609T与前列腺癌存在显著关联。在按种族分层时，我们的分析表明，在亚洲人中，使用显性模型（TT + CT vs CC：OR = 1.419，95%CI = 1.053 - 1.913，P = 0.021）和等位基因模型（OR = 1.337，95%CI = 1.014 - 1.763，P = 0.040）分析数据时，NQO1基因C609T与前列腺癌风险相关。然而，在白种人中未发现显著关联。这项荟萃分析表明，NQO1基因C609T多态性很可能导致亚洲人患前列腺癌的易感性增加。需要进一步开展大规模、设计良好的病例对照研究，以验证本荟萃分析中确定的风险。
