Gul Isil Gogcegoz, Karlidag Rifat, Cumurcu Birgul Elbozan, Turkoz Yusuf, Kartalci Sukru, Ozcan A Cemal, Erdemli M Erman
Uskudar University, Department of Psychiatry, Istanbul, Turkey.
Inonu University Faculty of Medicine, Department of Psychiatry, Malatya, Turkey.
Psychiatry Investig. 2013 Dec;10(4):317-25. doi: 10.4306/pi.2013.10.4.317. Epub 2013 Dec 16.
We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
我们旨在调查惊恐障碍（PD）中的广场恐惧症（A）是否对氧化和抗氧化参数有任何影响。我们使用来自总共31名患有广场恐惧症的惊恐障碍患者、22名无广场恐惧症的惊恐障碍患者和53名对照组受试者的血液样本，测量了总抗氧化能力（TAC）、对氧磷酶（PON）、芳基酯酶（ARE）抗氧化剂和丙二醛（MDA）氧化剂水平。由患有广场恐惧症的惊恐障碍患者、无广场恐惧症的惊恐障碍患者和对照组组成的三组之间，TAC、PON、ARE和MDA水平存在显著差异。为明确造成差异的组进行的双向比较表明，与对照组相比，患有广场恐惧症的惊恐障碍患者组的TAC、PON和ARE抗氧化剂显著较低，而MDA氧化剂显著较高。无广场恐惧症的惊恐障碍患者组与对照组在TAC、PON、ARE和MDA水平上没有显著差异。我们清楚地证明，患有广场恐惧症的惊恐障碍患者组的氧化应激和抗氧化机制损伤显著更高。这些发现表明，氧化/抗氧化机制可能在伴有广场恐惧症的惊恐障碍的发病机制中发挥更重要的作用。
