Machado-Vieira Rodrigo, Andreazza Ana Cristina, Viale Carlos Ivan, Zanatto Vanessa, Cereser Victor, da Silva Vargas Rafael, Kapczinski Flávio, Portela Luiz V, Souza Diogo O, Salvador Mirian, Gentil Valentim
Mood Disorders Program, HMIPV, Fundacao Faculdade Federal Ciencias Medicas de Porto Alegre and Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, Brazil.
Neurosci Lett. 2007 Jun 21;421(1):33-6. doi: 10.1016/j.neulet.2007.05.016. Epub 2007 May 22.
Studies have proposed the involvement of oxidative stress and neuronal energy dysfunctions in the pathophysiology of bipolar disorder (BD). This study evaluates plasma levels of the oxidative/energy metabolism markers, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and neuron-specific enolase (NSE) during initial episodes of mania compared to controls in 75 subjects. Two groups of manic subjects (unmedicated n=30, and lithium-treated n=15) were age/gender matched with healthy controls (n=30). TBARS and antioxidant enzymes activity (SOD and CAT) were increased in unmedicated manic patients compared to controls. Conversely, plasma NSE levels were lower during mania than in the controls. In contrast, acute treatment with lithium showed a significant reduction in both SOD/CAT ratio and TBARS levels. These results suggest that initial manic episodes are associated with both increased oxidative stress parameters and activated antioxidant defenses, which may be related to dysfunctions on energy metabolism and neuroplasticity pathways. Antioxidant effects using lithium in mania were shown, and further studies are necessary to evaluate the potential role of these effects in the pathophysiology and therapeutics of BD.
研究表明，氧化应激和神经元能量功能障碍参与了双相情感障碍（BD）的病理生理过程。本研究评估了75名受试者在躁狂发作初期与对照组相比，血浆中氧化/能量代谢标志物硫代巴比妥酸反应性物质（TBARS）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和神经元特异性烯醇化酶（NSE）的水平。两组躁狂受试者（未用药n = 30，锂治疗n = 15）在年龄/性别上与健康对照组（n = 30）相匹配。与对照组相比，未用药的躁狂患者TBARS和抗氧化酶活性（SOD和CAT）升高。相反，躁狂发作期间血浆NSE水平低于对照组。相比之下，锂的急性治疗使SOD/CAT比值和TBARS水平均显著降低。这些结果表明，初始躁狂发作与氧化应激参数增加和抗氧化防御激活均相关，这可能与能量代谢和神经可塑性途径的功能障碍有关。研究显示了锂在躁狂发作中的抗氧化作用，有必要进一步研究以评估这些作用在BD病理生理和治疗中的潜在作用。
