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脂蛋白(a)：在高血压病因中仅是旁观者吗？一项针对尚未接受治疗的原发性高血压患者的研究。

Lipoprotein (a): More than a bystander in the etiology of hypertension? A study on essential hypertensive patients not yet on treatment.

作者信息

Ghorbani Ali, Rafieian-Kopaei Mahmoud, Nasri Hamid

机构信息

Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

出版信息

J Nephropathol. 2013 Jan;2(1):67-70. doi: 10.5812/nephropathol.9092. Epub 2013 Jan 1.

DOI:10.5812/nephropathol.9092
PMID:24475427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3886175/
Abstract

BACKGROUND

Hypertension (HTN) is a very common disorder with a substantial impact on public health because of its complications.

OBJECTIVES

To study the association of serum lipoprotein(a) [Lp(a)] elevation with essential hypertension (eHTN).

PATIENTS AND METHODS

This study was conducted on a group of essential hypertensive patients. Laboratory exams consisting of serum creatinine and Lp(a) were measured.

RESULTS

Ninety five essential hypertensive patients were enrolled to the study. Serum LP (a) in patients was 46.5±20. In patients an inverse correlation between serum Lp(a) andcreatinine clearance was seen (r = -0.175 p<0.05). There was a significant correlation between serum Lp(a) and age (r =0.191 p<0.05) or duration of HTN (known duration of hypertension period) (r =0.362 p<0.05).

CONCLUSIONS

Our data suggest that Lp(a) may be involved as a cofactor in essential hypertension, with a mechanism that remains to be elucidated.

摘要

背景

高血压（HTN）是一种非常常见的疾病，因其并发症对公众健康有重大影响。

目的

研究血清脂蛋白（a）[Lp（a）]升高与原发性高血压（eHTN）的关联。

患者与方法

本研究针对一组原发性高血压患者进行。进行了包括血清肌酐和Lp（a）在内的实验室检查。

结果

95名原发性高血压患者纳入研究。患者血清LP（a）为46.5±20。患者血清Lp（a）与肌酐清除率呈负相关（r = -0.175，p<0.05）。血清Lp（a）与年龄（r = 0.191，p<0.05）或高血压病程（已知高血压时期的病程）（r = 0.362，p<0.05）之间存在显著相关性。

结论

我们的数据表明，Lp（a）可能作为原发性高血压的一个辅助因素参与其中，其机制尚待阐明。

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Clin Exp Med. 2001 Sep;1(3):145-50. doi: 10.1007/s10238-001-8026-z.
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Lp(a) in hypertensive patients.高血压患者中的脂蛋白(a)
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Association of serum lipoprotein(a) levels and apolipoprotein(a) size polymorphism with target-organ damage in arterial hypertension.动脉高血压患者血清脂蛋白(a)水平及载脂蛋白(a)大小多态性与靶器官损害的关系
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