Catalano M, Perilli E, Carzaniga G, Colombo F, Carotta M, Andreoni S
Research Center on Vascular Diseases, University of Milan, L. Sacco Hospital, Italy.
J Hum Hypertens. 1998 Feb;12(2):83-9. doi: 10.1038/sj.jhh.1000540.
Lipoprotein(a) (Lp(a)) is considered an important risk factor for coronary disease, cerebrovascular pathology and re-stenosis of coronary bypass. Few studies have been conducted on this lipoprotein in essential arterial hypertensive patients. The purpose of our study was to measure the serum concentrations of Lp(a) and the main parameters of the lipid profile in a group of essential hypertensive patients not receiving pharmacological treatment and with no clinical signs of associated pathologies or organ damage. A total of 123 Caucasian essential arterial hypertensive patients (47 men and 76 women) were studied and compared with 89 controls (36 men and 53 women) matched in terms of age, sex, body mass index (BMI) and smoking habits. It was found that the hypertensive patients had higher plasma concentrations of Lp(a), total cholesterol (TC), triglycerides (TG) and very low density lipoprotein (VLDL-C) than controls (P < 0.01), with no differences in the plasma concentrations of Lp(a) between the two sexes. Only 10 hypertension patients and seven controls had plasma concentrations of Lp(a) of over 30 mg/dl. Lp(a) does not correlate with the main parameters of the lipid profile. We can confirm that hypertension and dyslipidaemia, which are two of the main risk factors for vascular diseases on an atherosclerotic basis, are often associated. However, higher plasma concentrations of Lp(a), albeit within the normal range, could be an independent risk factor for atherosclerosis, and could contribute towards increasing the incidence of cardiovascular disease in people with essential arterial hypertension.
脂蛋白(a)（Lp(a)）被认为是冠心病、脑血管疾病和冠状动脉搭桥再狭窄的重要危险因素。针对原发性高血压患者的这种脂蛋白的研究较少。我们研究的目的是测量一组未接受药物治疗且无相关疾病或器官损害临床体征的原发性高血压患者的血清Lp(a)浓度和血脂谱的主要参数。共研究了123名白种人原发性高血压患者（47名男性和76名女性），并与89名在年龄、性别、体重指数（BMI）和吸烟习惯方面相匹配的对照组（36名男性和53名女性）进行比较。结果发现，高血压患者的血浆Lp(a)、总胆固醇（TC）、甘油三酯（TG）和极低密度脂蛋白（VLDL-C）浓度高于对照组（P<0.01），两性之间血浆Lp(a)浓度无差异。只有10名高血压患者和7名对照组患者血浆Lp(a)浓度超过30mg/dl。Lp(a)与血脂谱的主要参数无相关性。我们可以证实，高血压和血脂异常这两种基于动脉粥样硬化的血管疾病主要危险因素常常并存。然而，尽管血浆Lp(a)浓度在正常范围内，但较高水平可能是动脉粥样硬化的独立危险因素，并可能导致原发性高血压患者心血管疾病发病率增加。
