Ca 125免疫反应性及INI 1表达缺失是诊断外阴近端型上皮样肉瘤的有用标志物：两例报告

Immunoreactivity for Ca 125 and INI 1 loss of expression are useful markers in the diagnosis of vulvar proximal-type epithelioid sarcomas: report of two cases.

作者信息

Cossu A, Paliogiannis P, Capobianco G, Sini M C, Dessole M, Dessole S, Palmieri G

机构信息

Department of Surgical, Microsurgical, and Medical Sciences, University of Sassari, Sassari, Italy.

Department of Surgical, Microsurgical, and Medical Sciences, Gynecologic and Obstetric Clinic University of Sassari, Sassari, Italy.

出版信息

Eur J Gynaecol Oncol. 2013;34(5):469-72.

PMID:24475586

Abstract

Epithelioid sarcomas (ES) are rare soft tissue tumours of obscure histogenesis. Diagnosis is often difficult as specific morphological and immunohistochemical patterns do not exist. Two distinct clinico-pathological entities have been identified: the classic or distal type and the proximal type. Recently, immunohistochemical detection of Ca 125 was described in ES, as well as loss of INI 1 expression. The authors describe in this paper the morphological and immunohistochemical features of two cases of proximal ES of the vulva. Immunoreactivity for Ca 125 and loss of INI 1 expression were present in both cases. These results confirm previous observations in Asian reports showing that these markers can be used as immunohistochemical markers for the diagnostic assessment of ES.

摘要

上皮样肉瘤（ES）是一种组织发生不明的罕见软组织肿瘤。由于不存在特定的形态学和免疫组化模式，诊断往往很困难。已确定两种不同的临床病理实体：经典型或远端型以及近端型。最近，ES中描述了Ca 125的免疫组化检测以及INI 1表达缺失。作者在本文中描述了两例外阴近端ES的形态学和免疫组化特征。两例均存在Ca 125免疫反应性及INI 1表达缺失。这些结果证实了亚洲报告中的先前观察结果，表明这些标志物可作为ES诊断评估的免疫组化标志物。