链烷醇对海兔神经元早期钾电流的影响取决于链长。
Alkanol effects on early potassium currents in Aplysia neurons depend on chain length.
作者信息
Treistman S N, Wilson A
机构信息
Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545.
出版信息
Proc Natl Acad Sci U S A. 1987 Dec;84(24):9299-303. doi: 10.1073/pnas.84.24.9299.
The relationship between alkanol chain length and effects on the transient potassium current, IA, were examined in three identified Aplysia californica neurons with ethanol (EtOH), butanol (BuOH), and hexanol (HxOH). Qualitative differences were found when the actions of EtOH were compared with those of the longer-chain-length alcohols. Whereas EtOH primarily affected the decay time constant of IA, having minimal effects on amplitude, BuOH and HxOH exerted their major effect on the amplitude of IA, reducing it, while their effects on decay kinetics were much less pronounced. The effects of EtOH on IA decay are cell specific among identified neurons of the Aplysia nervous system. The actions of BuOH and HxOH did not mimic these interneuronal differences. These data, coupled with data previously reported by us and others, make it unlikely that EtOH exerts its actions on IA via perturbation of a bulk lipid phase within the membrane.
在三种已鉴定的加州海兔神经元中，研究了烷醇链长度与乙醇（EtOH）、丁醇（BuOH）和己醇（HxOH）对瞬时钾电流IA的影响之间的关系。当将EtOH的作用与长链醇的作用进行比较时，发现了质的差异。EtOH主要影响IA的衰减时间常数，对幅度的影响最小，而BuOH和HxOH对IA的幅度产生主要影响，使其降低，而它们对衰减动力学的影响则不太明显。在海兔神经系统已鉴定的神经元中，EtOH对IA衰减的影响具有细胞特异性。BuOH和HxOH的作用并未模拟这些中间神经元之间的差异。这些数据，再加上我们和其他人先前报道的数据，使得EtOH不太可能通过扰动膜内的整体脂质相来对IA发挥作用。
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