Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, China.
Environ Sci Pollut Res Int. 2014 May;21(9):6170-5. doi: 10.1007/s11356-013-2465-4. Epub 2014 Jan 30.
Manganese (Mn) is an essential mineral nutrient in mammals. The physiological role of Mn in animal models is well documented, but little is known about the adverse effects of Mn deficiency or overexposure in humans, including pregnancy outcomes such as birth weight. We examined the relationship of the maternal and cord blood Mn levels with birth weight in a cohort of 172 mother-infant pairs born in Shanghai, China. Non-linear spline and quadratic regression models were used to test the hypothesis of an inverted U-shaped association between the Mn levels and birth weight. The median (range) levels of Mn in the maternal and cord blood were 5.38 (2.34-30.37) μg/dL and 7.66 (2.57-34.23) μg/dL, respectively. An inverted U-shaped relationship was observed between maternal Mn and birth weight after adjusting for potential confounders. The birth weight increased with Mn levels up to 4.18 μg/dL, and a slight reduction in weight was observed at higher levels. The cord blood Mn levels were not found to be associated with birth weight. Both lower and higher Mn exposures are associated with lower birth weight, which may influence important developmental parameters; the association of higher Mn levels with lower weight was weak and imprecise.
锰（Mn）是哺乳动物必需的矿物质营养元素。动物模型中 Mn 的生理作用已有充分记录，但对于人类中 Mn 缺乏或过度暴露的不良影响知之甚少，包括出生体重等妊娠结局。我们在中国上海的 172 对母婴队列中，研究了母体和脐带血 Mn 水平与出生体重的关系。采用非线性样条和二次回归模型检验了 Mn 水平与出生体重之间呈倒 U 型关系的假设。母体和脐带血中 Mn 的中位数（范围）水平分别为 5.38（2.34-30.37）μg/dL 和 7.66（2.57-34.23）μg/dL。在调整了潜在混杂因素后，母体 Mn 与出生体重之间观察到倒 U 型关系。在 Mn 水平达到 4.18μg/dL 之前，出生体重随 Mn 水平增加而增加，而在更高水平时体重略有下降。脐带血 Mn 水平与出生体重无关。较低和较高的 Mn 暴露都与较低的出生体重有关，这可能会影响重要的发育参数；而较高 Mn 水平与较低体重的关联较弱且不精确。
