Yamauchi Kohichi, Kogashiwa Yasunao, Nakamura Takehiro, Moro Yorihisa, Nagafuji Hiroshi, Kohno Naoyuki
Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Head Neck. 2015 Jan;37(1):127-33. doi: 10.1002/hed.23526. Epub 2014 Jan 29.
The purpose of this study was to evaluate the efficacy of sentinel lymph node biopsy (SLNB) in early head and neck squamous cell carcinoma (HNSCC).
The PubMed database was searched for studies published before October 31, 2012. Pooled values for the sentinel lymph node identification rate, sensitivity, false-negative rate, negative predictive value, and accuracy were calculated.
A total of 16 studies (987 patients) was included. The pooled identification rate, sensitivity, false-negative rate, negative predictive value, and accuracy were 95.2%, 86.3%, 13.7%, 94.2%, and 95.0%, respectively. The subgroup with high methodological quality showed a mean identification rate of 95.4% for SLNB validation trials and 94.2% for SLNB alone trials, and mean sensitivity of 91.0% for SLNB validation trials and 84.2% for SLNB alone trials.
The SLNB procedure has shown a high sensitivity rate, but the pooled sensitivity and false-negative rate were worse in SLNB alone trials than in SLNB validation trials.
本研究旨在评估前哨淋巴结活检（SLNB）在早期头颈部鳞状细胞癌（HNSCC）中的疗效。
检索PubMed数据库中2012年10月31日前发表的研究。计算前哨淋巴结识别率、敏感性、假阴性率、阴性预测值和准确性的合并值。
共纳入16项研究（987例患者）。前哨淋巴结识别率、敏感性、假阴性率、阴性预测值和准确性的合并值分别为95.2%、86.3%、13.7%、94.2%和95.0%。方法学质量高的亚组显示，前哨淋巴结活检验证试验的平均识别率为95.4%，单纯前哨淋巴结活检试验为94.2%；前哨淋巴结活检验证试验的平均敏感性为91.0%，单纯前哨淋巴结活检试验为84.2%。
前哨淋巴结活检程序显示出较高的敏感性，但单纯前哨淋巴结活检试验的合并敏感性和假阴性率比前哨淋巴结活检验证试验更差。
