异染色质位置对环状性染色体的影响导致黑腹果蝇胚胎杀子致死。
Heterochromatin position effects on circularized sex chromosomes cause filicidal embryonic lethality in Drosophila melanogaster.
作者信息
Ferree Patrick M, Gomez Karina, Rominger Peter, Howard Dagnie, Kornfeld Hannah, Barbash Daniel A
机构信息
W. M. Keck Science Department, Claremont McKenna, Pitzer, and Scripps Colleges, Claremont, California 91711.
出版信息
Genetics. 2014 Apr;196(4):1001-5. doi: 10.1534/genetics.113.161075. Epub 2014 Jan 29.
Abstract
Some circularized X-Y chromosomes in Drosophila melanogaster are mitotically unstable and induce early embryonic lethality, but the genetic basis is unknown. Our experiments suggest that a large region of X-linked satellite DNA causes anaphase bridges and lethality when placed into a new heterochromatic environment within certain circularized X-Y chromosomes. These results reveal that repetitive sequences can be incompatible with one another in cis. The lethal phenotype also bears a remarkable resemblance to a case of interspecific hybrid lethality.
摘要
一些果蝇中的环状X-Y染色体在有丝分裂时不稳定，并会导致早期胚胎致死，但遗传基础尚不清楚。我们的实验表明，当X连锁卫星DNA的大片段被置于某些环状X-Y染色体内的新异染色质环境中时，会导致后期桥接和致死。这些结果表明，重复序列在顺式中可能彼此不相容。这种致死表型也与种间杂种致死的一个案例有显著相似之处。
相似文献
1
Heterochromatin position effects on circularized sex chromosomes cause filicidal embryonic lethality in Drosophila melanogaster.异染色质位置对环状性染色体的影响导致黑腹果蝇胚胎杀子致死。
Genetics. 2014 Apr;196(4):1001-5. doi: 10.1534/genetics.113.161075. Epub 2014 Jan 29.
2
Mitotic misbehavior of a Drosophila melanogaster satellite in ring chromosomes: insights into intragenomic conflict among heterochromatic sequences.果蝇环状染色体中一个卫星序列的有丝分裂异常行为：对异染色质序列间基因组内冲突的见解
Fly (Austin). 2014;8(2):101-7. doi: 10.4161/fly.29488.
3
Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in Drosophila.物种特异性异染色质防止有丝分裂染色体分离，导致果蝇杂种致死。
PLoS Biol. 2009 Oct;7(10):e1000234. doi: 10.1371/journal.pbio.1000234. Epub 2009 Oct 27.
4
Cytogenetical localization of Zygotic hybrid rescue (Zhr), a Drosophila melanogaster gene that rescues interspecific hybrids from embryonic lethality.合子杂种拯救基因（Zhr）的细胞遗传学定位，Zhr是一种能拯救种间杂种胚胎致死性的黑腹果蝇基因。
Mol Gen Genet. 1993 Jun;239(3):441-9. doi: 10.1007/BF00276943.
5
Filicidal ring-Y chromosomes in D. melanogaster.黑腹果蝇中具有杀子特性的环状Y染色体。
Genetics. 1982 Oct;102(2):245-58. doi: 10.1093/genetics/102.2.245.
6
Incompatibility between X chromosome factor and pericentric heterochromatic region causes lethality in hybrids between Drosophila melanogaster and its sibling species.X 染色体因子与着丝粒异染色质区之间的不兼容性导致黑腹果蝇与其姊妹种杂交种的致死。
Genetics. 2012 Jun;191(2):549-59. doi: 10.1534/genetics.112.139683. Epub 2012 Mar 23.
7
Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome.有毒 Y 染色体：年轻 Y 染色体的雄性果蝇中重复表达增加和与年龄相关的异染色质丢失。
PLoS Genet. 2021 Apr 22;17(4):e1009438. doi: 10.1371/journal.pgen.1009438. eCollection 2021 Apr.
8
The Hybrid Incompatibility Genes and Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function.杂种不亲和基因 和 对于后期姐妹染色单体的分离是必需的，但对于着丝粒功能不是必需的。
Genetics. 2017 Dec;207(4):1457-1472. doi: 10.1534/genetics.117.300390. Epub 2017 Oct 18.
9
Chromosomal position effects reveal different cis-acting requirements for rDNA transcription and sex chromosome pairing in Drosophila melanogaster.染色体位置效应揭示了黑腹果蝇中核糖体DNA转录和性染色体配对的不同顺式作用要求。
Genetics. 2000 Jul;155(3):1195-211. doi: 10.1093/genetics/155.3.1195.
10
Rescue from the abnormal oocyte maternal-effect lethality by ABO heterochromatin in Drosophila melanogaster.果蝇中ABO异染色质对异常卵母细胞母体效应致死性的拯救作用。
Genetics. 1991 Jul;128(3):583-94. doi: 10.1093/genetics/128.3.583.
引用本文的文献
1
Drosophila ring chromosomes interact with sisters and homologs to produce anaphase bridges in mitosis.果蝇环状染色体在有丝分裂过程中与姐妹染色单体和同源染色体相互作用，从而产生后期桥。
Genetics. 2024 Oct 25;228(4). doi: 10.1093/genetics/iyae169.
2
Drosophila ring chromosomes interact with sisters and homologs to produce anaphase bridges in mitosis.果蝇环状染色体在有丝分裂中与姐妹染色单体和同源染色体相互作用，产生后期桥。
bioRxiv. 2024 Aug 9:2024.08.08.607186. doi: 10.1101/2024.08.08.607186.
3
Dicentric chromosome breakage in Drosophila melanogaster is influenced by pericentric heterochromatin and occurs in nonconserved hotspots.果蝇中的着丝粒染色体断裂受着丝粒异染色质影响，并发生在非保守热点处。
Genetics. 2023 May 26;224(2). doi: 10.1093/genetics/iyad052.
4
Cross-species incompatibility between a DNA satellite and the Drosophila Spartan homolog poisons germline genome integrity.DNA 卫星与果蝇斯巴达同源物之间的跨物种不相容性会毒害生殖系基因组的完整性。
Curr Biol. 2022 Jul 11;32(13):2962-2971.e4. doi: 10.1016/j.cub.2022.05.009. Epub 2022 May 27.
5
Cytological analysis of cytoplasmic incompatibility induced by suggests convergent evolution with its distant cousin .由……诱导的细胞质不亲和性的细胞学分析表明，它与其远亲……存在趋同进化。 （注：原文中“suggests convergent evolution with its distant cousin.”部分缺失关键信息，翻译只能做到尽量还原已知部分）
Proc Biol Sci. 2017 Sep 13;284(1862). doi: 10.1098/rspb.2017.1433.
6
Unique sequence organization and small RNA expression of a "selfish" B chromosome.一条“自私”B染色体的独特序列组织和小RNA表达
Chromosoma. 2017 Dec;126(6):753-768. doi: 10.1007/s00412-017-0641-x. Epub 2017 Aug 5.
7
A genomic approach to identify hybrid incompatibility genes.一种用于鉴定杂种不亲和基因的基因组方法。
Fly (Austin). 2016 Jul 2;10(3):142-8. doi: 10.1080/19336934.2016.1193657. Epub 2016 May 26.
8
Preferential Breakpoints in the Recovery of Broken Dicentric Chromosomes in Drosophila melanogaster.果蝇中折断双着丝粒染色体的修复的优先断点。
Genetics. 2015 Oct;201(2):563-72. doi: 10.1534/genetics.115.181156. Epub 2015 Aug 20.
9
Mitotic misbehavior of a Drosophila melanogaster satellite in ring chromosomes: insights into intragenomic conflict among heterochromatic sequences.果蝇环状染色体中一个卫星序列的有丝分裂异常行为：对异染色质序列间基因组内冲突的见解
Fly (Austin). 2014;8(2):101-7. doi: 10.4161/fly.29488.
10
Normal segregation of a foreign-species chromosome during Drosophila female meiosis despite extensive heterochromatin divergence.尽管异染色质存在广泛差异，但果蝇雌性减数分裂过程中外源物种染色体仍能正常分离。
Genetics. 2015 Jan;199(1):73-83. doi: 10.1534/genetics.114.172072. Epub 2014 Nov 17.
本文引用的文献
1
A simple and rapid method for constructing ring-X chromosomes in Drosophila melanogaster.一种在黑腹果蝇中构建环状X染色体的简单快速方法。
Chromosoma. 2011 Apr;120(2):159-64. doi: 10.1007/s00412-010-0297-2. Epub 2010 Nov 18.
2
Systematic protein location mapping reveals five principal chromatin types in Drosophila cells.系统蛋白质定位图谱揭示了果蝇细胞中的五种主要染色质类型。
Cell. 2010 Oct 15;143(2):212-24. doi: 10.1016/j.cell.2010.09.009. Epub 2010 Sep 30.
3
Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in Drosophila.物种特异性异染色质防止有丝分裂染色体分离，导致果蝇杂种致死。
PLoS Biol. 2009 Oct;7(10):e1000234. doi: 10.1371/journal.pbio.1000234. Epub 2009 Oct 27.
4
Distorted sex ratios: a window into RNAi-mediated silencing.扭曲的性别比例：RNA干扰介导的基因沉默之窗。
PLoS Biol. 2007 Nov 6;5(11):e303. doi: 10.1371/journal.pbio.0050303.
5
Transcription and RNA interference in the formation of heterochromatin.异染色质形成过程中的转录与RNA干扰
Nature. 2007 May 24;447(7143):399-406. doi: 10.1038/nature05914.
6
A Cytological Study of W Chromosome Instability in Cleavage Mitoses of Drosophila Melanogaster.黑腹果蝇卵裂有丝分裂中W染色体不稳定性的细胞学研究。
Genetics. 1959 Sep;44(5):923-31. doi: 10.1093/genetics/44.5.923.
7
The Behavior of an Unstable Ring Chromosome of Drosophila Melanogaster.黑腹果蝇一条不稳定环状染色体的行为
Genetics. 1955 Nov;40(6):951-61. doi: 10.1093/genetics/40.6.951.
8
Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide.一种特异性聚酰胺使D1、HP1和拓扑异构酶II从卫星异染色质上移位。
EMBO J. 2006 Jun 7;25(11):2397-408. doi: 10.1038/sj.emboj.7601125. Epub 2006 May 4.
9
The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells.人类肿瘤细胞和非肿瘤细胞中环状染色体的结构与动态变化
Hum Genet. 1999 Apr;104(4):315-25. doi: 10.1007/s004390050960.
10
Mapping simple repeated DNA sequences in heterochromatin of Drosophila melanogaster.绘制黑腹果蝇异染色质中的简单重复DNA序列图谱。
Genetics. 1993 Aug;134(4):1149-74. doi: 10.1093/genetics/134.4.1149.
Zotero 插件