Hirose K, Hakozaki M, Kakuchi J, Matsunaga K, Yoshikumi C, Takahashi M, Tochikura T S, Yamamoto N
Biomedical Research Laboratory, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
Biochem Biophys Res Commun. 1987 Dec 16;149(2):562-7. doi: 10.1016/0006-291x(87)90404-9.
We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important in its anti-HIV effect as well as its inhibitory effect on the binding of HIV with lymphocytes.
我们发现，PSK在体外对人类免疫缺陷病毒（HIV）具有抗病毒作用。这种作用的机制之一是抑制HIV与淋巴细胞的结合。在此，我们发现PSK在体外以非竞争性方式抑制逆转录酶。这种抑制作用在其抗HIV作用以及对HIV与淋巴细胞结合的抑制作用中可能都很重要。
