用于治疗1型人类免疫缺陷病毒（HIV-1）感染的非核苷类逆转录酶抑制剂（NNRTIs）：克服耐药性产生的策略 - Suppr

Suppr

超能文献

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: strategies to overcome drug resistance development.

作者信息

de Clercq E

机构信息

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

出版信息

Med Res Rev. 1996 Mar;16(2):125-57. doi: 10.1002/(SICI)1098-1128(199603)16:2<125::AID-MED1>3.0.CO;2-2.

DOI:10.1002/(SICI)1098-1128(199603)16:2<125::AID-MED1>3.0.CO;2-2

PMID:8656777

Abstract

摘要

相似文献

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: strategies to overcome drug resistance development.用于治疗1型人类免疫缺陷病毒（HIV-1）感染的非核苷类逆转录酶抑制剂（NNRTIs）：克服耐药性产生的策略

Med Res Rev. 1996 Mar;16(2):125-57. doi: 10.1002/(SICI)1098-1128(199603)16:2<125::AID-MED1>3.0.CO;2-2.

Characteristics of a group of nonnucleoside reverse transcriptase inhibitors with structural diversity and potent anti-human immunodeficiency virus activity.一组具有结构多样性和强大抗人类免疫缺陷病毒活性的非核苷类逆转录酶抑制剂的特性。

Leukemia. 1995 Oct;9 Suppl 1:S75-85.

[Highly specific inhibitors of human immunodeficiency virus type I that are particularly targeted at the reverse transcriptase].[特别针对逆转录酶的I型人类免疫缺陷病毒的高度特异性抑制剂]

Pathol Biol (Paris). 1993 Mar;41(3):230-6.

In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques.表达1型人类免疫缺陷病毒逆转录酶的猿猴免疫缺陷病毒-人类免疫缺陷病毒嵌合体在猪尾猕猴体内的抗病毒耐药性体外特性研究

J Virol. 2004 Dec;78(24):13553-61. doi: 10.1128/JVI.78.24.13553-13561.2004.

[Mechanisms of HIV-1 drug resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors].

Mol Biol (Mosk). 2011 Jan-Feb;45(1):108-26.

Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors.猫免疫缺陷病毒/1型人类免疫缺陷病毒逆转录酶嵌合体对非核苷类逆转录酶抑制剂的敏感性。

Mol Pharmacol. 2004 Jan;65(1):244-51. doi: 10.1124/mol.65.1.244.

Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors.某些作为抗HIV-1药物的烯基二芳基甲烷的合成及生物学评价，这些烯基二芳基甲烷作为非核苷逆转录酶抑制剂发挥作用。

J Med Chem. 1996 Aug 2;39(16):3217-27. doi: 10.1021/jm960082v.

HIV-1 drug resistance. Molecular pathogenesis and laboratory monitoring.HIV-1耐药性。分子发病机制与实验室监测。

Clin Lab Med. 1994 Jun;14(2):393-422.

Is there a role for non-nucleoside reverse transcriptase inhibitors in the treatment of HIV infection?非核苷类逆转录酶抑制剂在治疗HIV感染中是否有作用？

Infect Agents Dis. 1994 Dec;3(6):313-23.

[Resistance to azidothymidine in human immunodeficiency virus (HIV) infection].[人类免疫缺陷病毒（HIV）感染中对叠氮胸苷的耐药性]

Mol Biol (Mosk). 1994 Jan-Feb;28(1):7-20.

引用本文的文献

Antiviral properties of caffeic acid phenethyl ester and its potential application.咖啡酸苯乙酯的抗病毒特性及其潜在应用。

J Intercult Ethnopharmacol. 2015 Oct-Dec;4(4):344-7. doi: 10.5455/jice.20151012013034. Epub 2015 Nov 5.

Theoretical investigation of the interactions in binding pocket of Reverse Transcriptase.逆转录酶结合口袋中相互作用的理论研究

Saudi J Biol Sci. 2015 Nov;22(6):719-24. doi: 10.1016/j.sjbs.2014.12.011. Epub 2014 Dec 31.

Bioactivity and chemical synthesis of caffeic acid phenethyl ester and its derivatives.咖啡酸苯乙酯及其衍生物的生物活性与化学合成

Molecules. 2014 Oct 13;19(10):16458-76. doi: 10.3390/molecules191016458.

Novel theoretically designed HIV-1 non-nucleoside reverse transcriptase inhibitors derived from nevirapine.新型理论设计的源自奈韦拉平的HIV-1非核苷逆转录酶抑制剂。

J Mol Model. 2014 Oct;20(10):2451. doi: 10.1007/s00894-014-2451-x. Epub 2014 Sep 20.

Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.基于蛋白质-蛋白质和蛋白质-化学相互作用网络鉴定具有 HIV 潜在治疗作用的化学物质。

PLoS One. 2013 Jun 6;8(6):e65207. doi: 10.1371/journal.pone.0065207. Print 2013.

HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors.HIV-1 逆转录酶（RT）的 172K 多态性抑制了临床相关的核苷和非核苷 RT 抑制剂耐药突变的效果。

J Biol Chem. 2012 Aug 24;287(35):29988-99. doi: 10.1074/jbc.M112.351551. Epub 2012 Jul 2.

Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.在 HIV-1 感染者中，amdoxovir 与齐多夫定低剂量和标准剂量之间不存在药代动力学相互作用。

Antimicrob Agents Chemother. 2010 Mar;54(3):1248-55. doi: 10.1128/AAC.01209-09. Epub 2009 Dec 28.

Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).广谱抗HIV药物（3'R,4'R）-3-氰基甲基-4-甲基-3',4'-二-O-（S）-樟脑酰基-（+）-顺式凯拉内酯（3-氰基甲基-4-甲基-DCK）的研发及临床前研究

J Med Chem. 2008 Dec 25;51(24):7689-96. doi: 10.1021/jm8003009.

Pharmacokinetics of BILR 355 after multiple oral doses coadministered with a low dose of ritonavir.多次口服BILR 355与低剂量利托那韦合用时的药代动力学。

Antimicrob Agents Chemother. 2009 Jan;53(1):95-103. doi: 10.1128/AAC.00752-08. Epub 2008 Oct 27.

Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model.使用群体药代动力学和酶动力学模拟模型，开发齐多夫定与选择K65R突变的药物联合制剂的优化剂量。

Antimicrob Agents Chemother. 2008 Dec;52(12):4241-50. doi: 10.1128/AAC.00054-08. Epub 2008 Oct 6.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验