免疫疗法对肿瘤浸润性T淋巴细胞（TICLs）对实体瘤侵袭反应的影响。

Effect of immunotherapy on the response of TICLs to solid tumour invasion.

作者信息

Mambili-Mamboundou Hermane, Sibanda Precious, Malinzi Joseph

机构信息

University of Kwazulu Natal, School of Mathematics, Statistics, and Computer Science, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa.

出版信息

Math Biosci. 2014 Mar;249:52-9. doi: 10.1016/j.mbs.2014.01.002. Epub 2014 Jan 27.

DOI:10.1016/j.mbs.2014.01.002

PMID:24480736

Abstract

There is clinical evidence that some people have lived with a benign tumour for their entire life time. This is explained by cancer dormancy which is attributed to the interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We present two mathematical models to study the mechanism of interaction of TICLs with tumour cells, with and without clinical intervention. Stability analysis and numerical simulations of the models reveal the existence of a stable tumour dormant state.

摘要

有临床证据表明，一些人一生都携带着良性肿瘤。这可以通过癌症休眠来解释，癌症休眠归因于肿瘤浸润性细胞毒性淋巴细胞（TICLs）与肿瘤细胞之间的相互作用。我们提出了两个数学模型来研究TICLs与肿瘤细胞相互作用的机制，包括有无临床干预的情况。对模型的稳定性分析和数值模拟揭示了稳定肿瘤休眠状态的存在。