Zhang Ling-Fei, Jiang Shuai, Liu Mo-Fang
Center for RNA Research, State Key Laboratory of Molecular Biology, University of Chinese Academy of Sciences, CAS Center for Excellence in Molecular Cell Science, Shanghai, China.
Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Cell Mol Life Sci. 2017 Aug;74(16):2929-2941. doi: 10.1007/s00018-017-2508-y. Epub 2017 Mar 20.
The reprogramming of glucose metabolism from oxidative to glycolytic metabolism, known as the Warburg effect, is an anomalous characteristic of cancer cell metabolism. Recent studies have revealed a subset of microRNAs (miRNAs) that play critical roles in regulating the reprogramming of glucose metabolism in cancer cells. These miRNAs regulate cellular glucose metabolism by directly targeting multiple metabolic genes, including those encoding key glycolytic enzymes. In the first part of this review, we summarized the recent knowledge of miRNA regulation in the reprogramming of glucose metabolism in cancer cells and discussed the potential utilization of the key miRNA regulators as metabolic targets for developing new antitumor agents. Then, we summarized recent advances in methods and techniques for studying miRNA regulation in cancer cell metabolism.
葡萄糖代谢从氧化代谢重编程为糖酵解代谢，即所谓的瓦伯格效应，是癌细胞代谢的一个异常特征。最近的研究揭示了一部分微小RNA（miRNA）在调节癌细胞葡萄糖代谢重编程中发挥关键作用。这些miRNA通过直接靶向多个代谢基因来调节细胞葡萄糖代谢，包括那些编码关键糖酵解酶的基因。在本综述的第一部分，我们总结了miRNA在癌细胞葡萄糖代谢重编程调控方面的最新知识，并讨论了关键miRNA调节因子作为开发新型抗肿瘤药物的代谢靶点的潜在应用。然后，我们总结了研究癌细胞代谢中miRNA调控的方法和技术的最新进展。
