Bhowmik T, Mukherjea M
Department of Biochemistry, University College of Science, Calcutta University, India.
Contraception. 1987 Aug;36(2):227-37. doi: 10.1016/0010-7824(87)90018-7.
The effect of norethisterone enanthate (NET-EN) on cervical mucus protein, sialic acid and some enzymes (e.g. peroxidase, alkaline phosphatase and alpha-amylase) were studied in adult female rats. One mg NET-EN every 12 days was found to be an effective contraceptive dose of this drug in this species, acting primarily through the cervical mucus. NET-EN produced a highly significant increase in protein content and peroxidase and alkaline phosphatase activities. However, sialic acid content and amylase activity did not exhibit any definite pattern after NET-EN therapy. The increased protein content together with persistent elevated levels of peroxidase and alkaline phosphatase corroborates the hypothesis that NET-EN creates a progestogenic phase which prevents sperm penetration and thus conception.
研究了庚酸炔诺酮（NET-EN）对成年雌性大鼠宫颈黏液蛋白、唾液酸及某些酶（如过氧化物酶、碱性磷酸酶和α-淀粉酶）的影响。发现每12天给予1毫克NET-EN是该药物在该物种中的有效避孕剂量，其主要通过宫颈黏液起作用。NET-EN使蛋白质含量以及过氧化物酶和碱性磷酸酶活性显著增加。然而，NET-EN治疗后唾液酸含量和淀粉酶活性未呈现任何明确规律。蛋白质含量增加以及过氧化物酶和碱性磷酸酶水平持续升高证实了NET-EN会形成一个孕激素期从而阻止精子穿透进而防止受孕的假说。
