Akhter N, Choudhury S A
Bangladesh Med Res Counc Bull. 1981 Dec;7(2):52-8.
The effect of Norethisterone-oenanthate (NET-OEN), a long acting injectable contraceptive on cervical spinnbarkeit and protein content were studied in adult female virgin rats. A single injection of NET-OEN (1 mg/rat) and sacrificed after 3 vaginal cycles produced a highly significant reduction (P less than 0.001) in the spinnbarkeit and a non-significant increase in the protein content of the cervical mucus. But two successive injections of NET-OEN (1 mg/rat each) produced a highly significant decrease (P less than 0.001) in the spinnbarkeit as well as a significant increase (P less than 0.01) in the protein content. The increased protein content of cervical mucus corroborates the hypothesis that NET-OEN exerts its contraceptive effect primarily through effect on cervical mucus.
在成年未孕雌性大鼠中研究了长效注射用避孕药庚炔诺酮（NET - OEN）对宫颈黏液延展性和蛋白质含量的影响。单次注射NET - OEN（1毫克/只大鼠），在3个阴道周期后处死，结果显示宫颈黏液延展性显著降低（P < 0.001），而宫颈黏液蛋白质含量无显著增加。但是连续两次注射NET - OEN（每次1毫克/只大鼠），宫颈黏液延展性显著降低（P < 0.001），同时蛋白质含量显著增加（P < 0.01）。宫颈黏液中蛋白质含量的增加证实了以下假说，即NET - OEN主要通过对宫颈黏液的作用发挥其避孕效果。
