解析隐窝动力学模型中的肠道干细胞行为。
Unraveling intestinal stem cell behavior with models of crypt dynamics.
机构信息
Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
出版信息
Integr Biol (Camb). 2014 Mar;6(3):243-57. doi: 10.1039/c3ib40163d. Epub 2014 Jan 30.
Abstract
The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated. Recent discoveries have started to clarify the nature of ISCs, but many questions remain. This review discusses the current advances and controversies of ISC biology as well as theoretical compartmental models that have been coupled with in vivo experimentation to investigate the mechanisms of ISC dynamics during homeostasis, tumorigenesis, repair and development. We conclude our review by discussing the key lingering questions in the field and proposing how many of these questions can be addressed using both compartmental models and experimental techniques.
摘要
肠道干细胞（ISCs）的定义、调控和功能一直是激烈争论的焦点。最近的发现开始阐明 ISCs 的本质，但仍有许多问题悬而未决。本文讨论了 ISC 生物学的最新进展和争议，以及与体内实验相结合的理论分区模型，以研究 ISC 在稳态、肿瘤发生、修复和发育过程中的动态机制。最后，我们讨论了该领域中仍然存在的关键问题，并提出了如何使用分区模型和实验技术来解决其中的许多问题。
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