Hager K, Breidung R
Institut für Gerontologie Universität Erlangen, Nürnberg, BRD.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(5):646-55.
Thrombocytes of male donors of different age groups were investigated in terms of their content of N-acetylneuraminic acid (NANA) and protein. For this purpose NANA was split up hydrolytically as well as enzymatically by neuraminidase. Furthermore, the relation of NANA to protein was determined in the lysed thrombocytes of these donors. A significant increase in the protein content of platelets could be observed between group I and III (young and old donors). The relation of NANA to protein (acid hydrolysis) existing between these groups decreased significantly with growing age. Appropriate results could also be attained after having made a separate analysis in lysed thrombocytes. The results achieved allow the conclusion to be drawn that there is a changed thrombocytopoiesis in men of old age.
对不同年龄组男性献血者的血小板进行了N-乙酰神经氨酸（NANA）含量和蛋白质含量的研究。为此，通过水解以及用神经氨酸酶进行酶解来分离NANA。此外，还测定了这些献血者裂解血小板中NANA与蛋白质的关系。在I组和III组（年轻和年老献血者）之间可观察到血小板蛋白质含量显著增加。随着年龄增长，这些组之间存在的NANA与蛋白质的关系（酸水解）显著降低。在裂解血小板中进行单独分析后也能得到相应结果。所取得的结果可以得出结论，老年男性的血小板生成发生了变化。
