Robey Pamela Gehron, Kuznetsov Sergei A, Riminucci Mara, Bianco Paolo
National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA.
Sapienza University of Rome, Rome, Italy.
Methods Mol Biol. 2014;1130:279-293. doi: 10.1007/978-1-62703-989-5_21.
Populations of bone marrow stromal cells (BMSCs, also known as bone marrow-derived "mesenchymal stem cells") contain a subset of cells that are able to recapitulate the formation of a bone/marrow organ (skeletal stem cells, SSCs). The biological properties of BMSC cultures are assessed by a variety of assays, both in vitro and in vivo. Application of these assays in an appropriate fashion provides a great deal of information on the role of BMSCs, and the subset of SSCs, in health and in disease.
骨髓基质细胞群体（BMSCs，也称为骨髓来源的“间充质干细胞”）包含能够重现骨/骨髓器官形成的细胞亚群（骨骼干细胞，SSCs）。通过多种体外和体内试验评估BMSC培养物的生物学特性。以适当方式应用这些试验可提供大量有关BMSCs以及SSCs亚群在健康和疾病中的作用的信息。
