间充质干细胞：重温历史、概念与检测方法
Mesenchymal stem cells: revisiting history, concepts, and assays.
作者信息
Bianco Paolo, Robey Pamela Gehron, Simmons Paul J
出版信息
Cell Stem Cell. 2008 Apr 10;2(4):313-9. doi: 10.1016/j.stem.2008.03.002.
Abstract
The concept of mesenchymal stem cells has gained wide popularity. Despite the rapid growth of the field, uncertainties remain with respect to the defining characteristics of these cells, including their potency and self-renewal. These uncertainties are reflected in a growing tendency to question the very use of the term. This commentary revisits the experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their stemness and function.
摘要
间充质干细胞的概念已广为人知。尽管该领域发展迅速，但关于这些细胞的定义特征，包括其分化潜能和自我更新能力，仍存在不确定性。这些不确定性反映在对该术语本身使用的质疑日益增加的趋势中。本评论重新审视了被称为间充质干细胞群体概念的实验起源，以及评估其干性和功能所需的实验框架。
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